Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 10/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4941647 | 0.87 | FTO (0.52) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL2314510 | 0.86 | FTO (0.60) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL19206099 | 0.85 | FTO (0.50) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL8196841 | 0.83 | FTO (0.48) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL3788322 | 0.83 | FTO (0.48) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL239423 | 0.81 | HPGD (0.55) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL20438530 | 0.81 | FTO (0.54) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL16010027 | 0.81 | FTO (0.51) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL17956696 | 0.81 | FTO (0.57) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL3485942 | 0.79 | HPGD (0.50) | FTOMAPTHPGDMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116525-B1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | UNIV CALIFORNIA (US) | 2021-06-23 | — | — | EP | disclosed |
| CN-106659796-B | TCO conjugates and therapeutic agent delivery methods | 加利福尼亚大学董事会 | 2021-04-30 | — | — | CN | disclosed |
| US-20210060188-A1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 2021-03-04 | — | — | US | disclosed |
| US-10806807-B2 | TCO conjugates and methods for delivery of therapeutic agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-10-20 | — | — | US | disclosed |
| US-10342882-B2 | TCO conjugates and methods for delivery of therapeutic agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-07-09 | — | — | US | disclosed |
| US-20190111163-A1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-04-18 | — | — | US | disclosed |
| US-10130723-B2 | TCO conjugates and methods for delivery of therapeutic agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-11-20 | — | — | US | disclosed |
| US-20170095580-A1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-04-06 | — | — | US | disclosed |
| US-20170087258-A1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 2017-03-30 | — | — | US | disclosed |
| EP-3116525-A1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | The Regents of the University of California (US) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015139025-A1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10342882-B2 | TCO conjugates and methods for delivery of therapeutic agents | FCGR2A, PAICS, CD47 | FTO 4286/4885MAPT 2413/4885HPGD 3830/4885 |
| US-20210060188-A1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | FCGR2A, PAICS, CD47 | FTO 4286/4885MAPT 2413/4885HPGD 3830/4885 |
| US-20170095580-A1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | FCGR2A, PAICS, CD47 | FTO 4286/4885MAPT 2413/4885HPGD 3830/4885 |
| US-20170087258-A1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | FCGR2A, PAICS, CD47 | FTO 4286/4885MAPT 2413/4885HPGD 3830/4885 |
| US-10806807-B2 | TCO conjugates and methods for delivery of therapeutic agents | FCGR2A, PAICS, CD47 | FTO 4286/4885MAPT 2413/4885HPGD 3830/4885 |
| US-10130723-B2 | TCO conjugates and methods for delivery of therapeutic agents | FCGR2A, PAICS, CD47 | FTO 4286/4885MAPT 2413/4885HPGD 3830/4885 |
| US-20190111163-A1 | TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | FCGR2A, PAICS, CD47 | FTO 4286/4885MAPT 2413/4885HPGD 3830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.