Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14956179 | 1.00 | JAK3 (0.46) | JAK3BTKIRAK4DGAT1KCNH2 | |
| SCHEMBL14956530 | 1.00 | JAK3 (0.46) | JAK3BTKIRAK4DGAT1KCNH2 | |
| SCHEMBL18603810 | 0.86 | SYK (0.40) | JAK3BTKIRAK4KCNH2SYK | |
| SCHEMBL18603812 | 0.86 | JAK3 (0.38) | JAK3BTKIRAK4DGAT1KCNH2 | |
| SCHEMBL14955911 | 0.85 | JAK3 (0.39) | JAK3BTKIRAK4SYK | |
| SCHEMBL18283747 | 0.84 | JAK3 (0.41) | JAK3BTKIRAK4DGAT1KCNH2 | |
| SCHEMBL18283745 | 0.84 | JAK3 (0.41) | JAK3BTKIRAK4DGAT1KCNH2 | |
| SCHEMBL14961880 | 0.83 | JAK3 (0.58) | JAK3BTKIRAK4SYKHCRTR1 | |
| SCHEMBL14976231 | 0.80 | JAK3 (0.42) | JAK3BTKIRAK4SYK | |
| SCHEMBL14956520 | 0.79 | SYK (0.48) | JAK3BTKIRAK4DGAT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116506-A1 | 2-PYRAZINE CARBOXAMIDES AS SPLEEN TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015138273-A1 | 2-PYRAZINE CARBOXAMIDES AS SPLEEN TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-09-17 | — | — | WO | disclosed |