Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17079782 | 0.80 | JAK3 (0.46) | JAK3SYKBTKIRAK4 | |
| SCHEMBL14956179 | 0.80 | JAK3 (0.46) | JAK3SYKBTKIRAK4 | |
| SCHEMBL14956530 | 0.80 | JAK3 (0.46) | JAK3SYKBTKIRAK4 | |
| SCHEMBL17745697 | 0.78 | JAK2 (0.33) | JAK3SYKIRAK4 | |
| SCHEMBL14961880 | 0.78 | JAK3 (0.58) | JAK3SYKBTKIRAK4 | |
| SCHEMBL17745696 | 0.77 | SYK (0.44) | SYK | |
| SCHEMBL14976450 | 0.76 | SYK (0.57) | SYK | |
| SCHEMBL376771 | 0.75 | JAK3 (0.48) | JAK3SYKBTKIRAK4 | |
| SCHEMBL495955 | 0.73 | MEN1 (0.33) | IRAK4CHEK1RPS6KA3SRPK1 | |
| SCHEMBL18283495 | 0.73 | BTK (0.46) | JAK3SYKBTKIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782579-A1 | PYRAZINE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |