Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549448 | 1.00 | AKR1C3 (0.48) | AKR1C3ALDH1A1SMN1; SMN2MAPTGFER | |
| SCHEMBL549449 | 1.00 | AKR1C3 (0.48) | AKR1C3ALDH1A1SMN1; SMN2MAPTGFER | |
| SCHEMBL17082084 | 0.91 | KMT2A (0.49) | ALDH1A1SMN1; SMN2MAPTGFERCTSK | |
| SCHEMBL549478 | 0.91 | KMT2A (0.49) | ALDH1A1SMN1; SMN2MAPTGFERCTSK | |
| SCHEMBL549479 | 0.91 | KMT2A (0.49) | ALDH1A1SMN1; SMN2MAPTGFERCTSK | |
| SCHEMBL549158 | 0.87 | AKR1C3 (0.52) | AKR1C3ALDH1A1SMN1; SMN2MAPTGFER | |
| SCHEMBL17082145 | 0.87 | AKR1C3 (0.52) | AKR1C3ALDH1A1SMN1; SMN2MAPTGFER | |
| SCHEMBL549159 | 0.87 | AKR1C3 (0.52) | AKR1C3ALDH1A1SMN1; SMN2MAPTGFER | |
| SCHEMBL550354 | 0.87 | AKR1C3 (0.46) | AKR1C3ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL550355 | 0.87 | AKR1C3 (0.46) | AKR1C3ALDH1A1SMN1; SMN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |