Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 5/20 | 0.33 |
| ▸ | NPY2R | P49146 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4572366 | 1.00 | PDE7A (0.39) | PDE7AALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL4572364 | 0.92 | ALDH1A1 (0.42) | PDE7AALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL17082105 | 0.92 | ALDH1A1 (0.42) | PDE7AALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL10263404 | 0.90 | PDE7A (0.37) | PDE7AALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL17082109 | 0.90 | PDE7A (0.37) | PDE7AALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL551017 | 0.89 | KDM4E (0.42) | PDE7AALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL551018 | 0.89 | KDM4E (0.42) | PDE7AALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL4570165 | 0.89 | KDM4E (0.43) | PDE7AKDM4ENR1I3AADAT | |
| SCHEMBL2700347 | 0.89 | KDM4E (0.42) | PDE7AALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL551425 | 0.89 | KDM4E (0.42) | PDE7AALDH1A1HPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |