Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570164 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDTP53NPC1RAB9A | |
| SCHEMBL17082116 | 0.94 | ALDH1A1 (0.39) | SMN1; SMN2HPGDNPC1RAB9AMAPT | |
| SCHEMBL4570159 | 0.94 | ALDH1A1 (0.39) | SMN1; SMN2HPGDNPC1RAB9AMAPT | |
| SCHEMBL4570215 | 0.92 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDTP53NPC1RAB9A | |
| SCHEMBL17082193 | 0.92 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDTP53NPC1RAB9A | |
| SCHEMBL4570133 | 0.91 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDTP53NPC1RAB9A | |
| SCHEMBL17082120 | 0.91 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDTP53NPC1RAB9A | |
| SCHEMBL4570162 | 0.90 | PDE7A (0.38) | SMN1; SMN2HPGDTP53MAPTALDH1A1 | |
| SCHEMBL17082096 | 0.90 | PDE7A (0.38) | SMN1; SMN2HPGDTP53MAPTALDH1A1 | |
| SCHEMBL17082078 | 0.90 | HPGD (0.41) | SMN1; SMN2HPGDTP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |