Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.40 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549689 | 1.00 | HTR7 (0.45) | HTR7KDM4EABL1LMNACXCR3 | |
| SCHEMBL550399 | 0.91 | HTR7 (0.47) | HTR7KDM4EABL1LMNACXCR3 | |
| SCHEMBL549371 | 0.89 | KDM4E (0.45) | HTR7KDM4EABL1LMNACXCR3 | |
| SCHEMBL549186 | 0.89 | KDM4E (0.45) | HTR7KDM4EABL1LMNACXCR3 | |
| SCHEMBL550341 | 0.89 | KDM4E (0.45) | HTR7KDM4EABL1LMNACXCR3 | |
| SCHEMBL549187 | 0.89 | KDM4E (0.45) | HTR7KDM4EABL1LMNACXCR3 | |
| SCHEMBL550342 | 0.89 | KDM4E (0.45) | HTR7KDM4EABL1LMNACXCR3 | |
| SCHEMBL549372 | 0.89 | KDM4E (0.45) | HTR7KDM4EABL1LMNACXCR3 | |
| SCHEMBL550575 | 0.88 | HTR7 (0.45) | HTR7KDM4EABL1LMNACXCR3 | |
| SCHEMBL550607 | 0.88 | HTR7 (0.45) | HTR7KDM4EABL1LMNACXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |