Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549404 | 1.00 | HTR7 (0.40) | HTR7KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL17082077 | 0.87 | SMN1; SMN2 (0.43) | HTR7KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL550732 | 0.87 | SMN1; SMN2 (0.43) | HTR7KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL17082054 | 0.87 | MAOB (0.41) | HTR7KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL549626 | 0.87 | MAOB (0.41) | HTR7KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL549474 | 0.85 | HTR7 (0.41) | HTR7KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL17082033 | 0.85 | HTR7 (0.41) | HTR7KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL549667 | 0.85 | GAA (0.53) | HTR7KDM4EPKMHPGDPOLB | |
| SCHEMBL550515 | 0.85 | KDM4E (0.53) | KDM4ESMN1; SMN2LMNAHTTPKM | |
| SCHEMBL17082062 | 0.85 | KDM4E (0.53) | KDM4ESMN1; SMN2LMNAHTTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |