Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FSHR | P23945 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17082191 | 1.00 | ALDH1A1 (0.36) | ALDH1A1RAB9ANPC1MAPTCASP3 | |
| SCHEMBL4570147 | 1.00 | ALDH1A1 (0.36) | ALDH1A1RAB9ANPC1MAPTCASP3 | |
| SCHEMBL4570219 | 1.00 | ALDH1A1 (0.36) | ALDH1A1RAB9ANPC1MAPTCASP3 | |
| SCHEMBL17082072 | 0.94 | SMN1; SMN2 (0.38) | ALDH1A1RAB9ANPC1MAPTOGA | |
| SCHEMBL4570148 | 0.94 | SMN1; SMN2 (0.38) | ALDH1A1RAB9ANPC1MAPTOGA | |
| SCHEMBL17082038 | 0.94 | SMN1; SMN2 (0.38) | ALDH1A1RAB9ANPC1MAPTOGA | |
| SCHEMBL4570220 | 0.94 | SMN1; SMN2 (0.38) | ALDH1A1RAB9ANPC1MAPTOGA | |
| SCHEMBL17082168 | 0.92 | DHODH (0.34) | ALDH1A1OGADHODHOPRK1AADAT | |
| SCHEMBL17082142 | 0.92 | DHODH (0.34) | ALDH1A1OGADHODHOPRK1AADAT | |
| SCHEMBL4570146 | 0.92 | DHODH (0.34) | ALDH1A1OGADHODHOPRK1AADAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |