Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570214 | 1.00 | ALDH1A1 (0.39) | ALDH1A1NPC1RAB9AKDM4ERECQL | |
| SCHEMBL4570215 | 0.93 | SMN1; SMN2 (0.43) | ALDH1A1NPC1RAB9AKDM4ERECQL | |
| SCHEMBL17082193 | 0.93 | SMN1; SMN2 (0.43) | ALDH1A1NPC1RAB9AKDM4ERECQL | |
| SCHEMBL4570159 | 0.92 | ALDH1A1 (0.39) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL17082116 | 0.92 | ALDH1A1 (0.39) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL4570213 | 0.91 | KDM4E (0.41) | ALDH1A1NPC1RAB9AKDM4ERECQL | |
| SCHEMBL4570135 | 0.91 | ALDH1A1 (0.38) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL17082101 | 0.91 | ALDH1A1 (0.38) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL17082172 | 0.89 | PDE7A (0.39) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL4572363 | 0.89 | PDE7A (0.39) | ALDH1A1NPC1RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |