Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PLK1 | P53350 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.32 |
| ▸ | F9 | P00740 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570187 | 1.00 | MAPT (0.33) | MAPTPLK1TTKOPRK1AADAT | |
| SCHEMBL4570223 | 1.00 | MAPT (0.33) | MAPTPLK1TTKOPRK1AADAT | |
| SCHEMBL17082154 | 1.00 | MAPT (0.33) | MAPTPLK1TTKOPRK1AADAT | |
| SCHEMBL3692653 | 0.93 | JAK2 (0.33) | MAPTPLK1TTKOPRK1AADAT | |
| SCHEMBL3692645 | 0.93 | JAK2 (0.33) | MAPTPLK1TTKOPRK1AADAT | |
| SCHEMBL2701142 | 0.93 | JAK2 (0.33) | MAPTPLK1TTKOPRK1AADAT | |
| SCHEMBL2700827 | 0.93 | JAK2 (0.33) | MAPTPLK1TTKOPRK1AADAT | |
| SCHEMBL2700832 | 0.93 | JAK2 (0.33) | MAPTPLK1TTKOPRK1AADAT | |
| SCHEMBL3707020 | 0.93 | JAK2 (0.33) | MAPTPLK1TTKOPRK1AADAT | |
| SCHEMBL4570222 | 0.93 | ALDH1A1 (0.35) | MAPTOPRK1PDE5AALDH1A1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |