Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | SLC6A12 | P48065 | 5/20 | 0.39 |
| ▸ | SLC6A11 | P48066 | 5/20 | 0.39 |
| ▸ | SLC6A13 | Q9NSD5 | 5/20 | 0.39 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067170 | 0.85 | HSD11B1 (0.61) | HSD11B1SLC6A12SLC6A11SLC6A13SLC6A1 | |
| SCHEMBL7859286 | 0.82 | HSD11B1 (0.58) | HSD11B1SLC6A12SLC6A11SLC6A13SLC6A1 | |
| SCHEMBL7046134 | 0.82 | HSD11B1 (0.58) | HSD11B1SLC6A12SLC6A11SLC6A13SLC6A1 | |
| SCHEMBL14128663 | 0.76 | HSD11B1 (0.41) | HSD11B1SLC6A12SLC6A11SLC6A13SLC6A1 | |
| SCHEMBL3754325 | 0.75 | HSD11B1 (0.56) | HSD11B1SLC6A12SLC6A11SLC6A13SLC6A1 | |
| SCHEMBL30707244 | 0.74 | HSD11B1 (0.50) | HSD11B1SLC6A12SLC6A11SLC6A13SLC6A1 | |
| SCHEMBL24631209 | 0.74 | HSD11B1 (0.50) | HSD11B1SLC6A12SLC6A11SLC6A13SLC6A1 | |
| SCHEMBL1787432 | 0.73 | HSD11B1 (1.00) | HSD11B1SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL14123210 | 0.73 | HSD11B1 (0.48) | HSD11B1SLC6A12SLC6A11SLC6A13SLC6A1 | |
| SCHEMBL9873869 | 0.73 | HSD11B1 (0.48) | HSD11B1SLC6A12SLC6A11SLC6A13ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054368-B1 | CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-09-16 | — | — | EP | disclosed |