Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708667 | 0.99 | ALDH1A1 (0.32) | ALDH1A1MAPTMAPK1MCHR1P2RX7 | |
| SCHEMBL1708677 | 0.90 | ALDH1A1 (0.32) | ALDH1A1MAPTMAPK1MCHR1P2RX7 | |
| SCHEMBL1708283 | 0.90 | ALDH1A1 (0.33) | ALDH1A1MAPTMAPK1MCHR1P2RX7 | |
| SCHEMBL1708673 | 0.89 | MAPT (0.33) | ALDH1A1MAPTMAPK1MCHR1 | |
| SCHEMBL1708661 | 0.89 | MAPT (0.33) | ALDH1A1MAPTMAPK1MCHR1 | |
| SCHEMBL1708620 | 0.89 | ALDH1A1 (0.32) | ALDH1A1MAPTMAPK1BACE1BACE2 | |
| SCHEMBL1707980 | 0.88 | ALDH1A1 (0.33) | ALDH1A1MAPTMAPK1BACE1BACE2 | |
| SCHEMBL1708666 | 0.86 | FFAR1 (0.37) | — | |
| SCHEMBL1708425 | 0.86 | NTRK1 (0.36) | ALDH1A1MAPTMAPK1MCHR1 | |
| SCHEMBL1708168 | 0.86 | NTRK1 (0.36) | ALDH1A1MAPTMAPK1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |