Sugi Predict

Sugi Predict / Compounds / SCHEMBL17083301

SCHEMBL17083301

SCHEMBL17083301

O=C(c1ccc(Oc2ccccc2)cc1)N(Cc1ccc(C2CCCCC2)cc1)c1ccccc1

nearest known ligand 0.83

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 7/20 0.83
▸ PTGES O14684 2/20 0.49
▸ ALOX5 P09917 2/20 0.49
▸ GCGR P47871 4/20 0.48
▸ NPC1 O15118 2/20 0.46
▸ MEN1 O00255 2/20 0.46
▸ KMT2A Q03164 2/20 0.46
▸ RAB9A P51151 1/20 0.46
▸ GIPR P48546 2/20 0.44
▸ LTB4R2 Q9NPC1 1/20 0.44
▸ LPAR1 Q92633 1/20 0.42
▸ LPAR5 Q9H1C0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17083302 0.93 STAT3 (0.79) STAT3PTGESALOX5GCGRNPC1
SCHEMBL17083303 0.93 STAT3 (0.79) STAT3PTGESALOX5GCGRMEN1
SCHEMBL25403432 0.91 STAT3 (0.76) STAT3PTGESALOX5GCGRGIPR
SCHEMBL25752441 0.91 STAT3 (0.76) STAT3PTGESALOX5GCGRGIPR
SCHEMBL26203441 0.91 STAT3 (0.76) STAT3PTGESALOX5GCGRNPC1
SCHEMBL17076888 0.91 STAT3 (1.00) STAT3PTGESALOX5GCGRGIPR
SCHEMBL17076921 0.90 STAT3 (1.00) STAT3PTGESALOX5GCGRGIPR
SCHEMBL17083304 0.90 STAT3 (0.75) STAT3PTGESALOX5NPC1MEN1
Phosphine SCHEMBL20327798 0.90 STAT3 (0.75) STAT3PTGESALOX5GCGRGIPR
SCHEMBL17083305 0.89 STAT3 (0.79) STAT3PTGESALOX5GCGRNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10954258-B2 STAT3 dimerization inhibitors H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2021-03-23 — — US disclosed
US-20200199160-A1 STAT3 DIMERIZATION INHIBITORS H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. 2020-06-25 — — US disclosed
US-20180179235-A1 STAT3 DIMERIZATION INHIBITORS H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. 2018-06-28 — — US disclosed
US-20180179235-A1 STAT3 DIMERIZATION INHIBITORS H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. 2018-06-28 — — US disclosed
US-9822135-B2 STAT3 dimerization inhibitors H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2017-11-21 — — US disclosed
US-9822135-B2 STAT3 dimerization inhibitors H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2017-11-21 — — US disclosed
US-20150259366-A1 STAT3 DIMERIZATION INHIBITORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-09-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200199160-A1 STAT3 DIMERIZATION INHIBITORS STAT3, JAK2, STAT1 STAT3 1/4885PTGES 2340/4885ALOX5 3394/4885
US-20180179235-A1 STAT3 DIMERIZATION INHIBITORS STAT3, JAK2, STAT1 STAT3 1/4885PTGES 2340/4885ALOX5 3394/4885
US-10954258-B2 STAT3 dimerization inhibitors STAT3, JAK2, STAT1 STAT3 1/4885PTGES 2340/4885ALOX5 3394/4885
US-20150259366-A1 STAT3 DIMERIZATION INHIBITORS STAT3, JAK2, STAT1 STAT3 1/4885PTGES 2340/4885ALOX5 3394/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.