Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8984177 | 1.00 | KMT2A (0.55) | KMT2AALOX5L3MBTL1TDP1FFAR2 | |
| SCHEMBL5510967 | 0.85 | ESR1 (0.57) | KMT2AFFAR2ESR1ESR2AKR1C3 | |
| SCHEMBL22838087 | 0.85 | KMT2A (0.55) | KMT2AALOX5L3MBTL1FFAR2LMNA | |
| SCHEMBL5516974 | 0.85 | ESR1 (0.57) | KMT2AFFAR2ESR1ESR2AKR1C3 | |
| SCHEMBL2422613 | 0.85 | ESR1 (0.57) | KMT2AFFAR2ESR1ESR2AKR1C3 | |
| SCHEMBL9908240 | 0.83 | KMT2A (0.53) | KMT2AFFAR2LMNAESR1ESR2 | |
| SCHEMBL1885337 | 0.83 | KMT2A (0.58) | KMT2AALOX5TDP1FFAR2ESR1 | |
| SCHEMBL5317090 | 0.83 | AKR1C3 (0.54) | KMT2AALOX5ACHEAKR1C3AKR1C2 | |
| SCHEMBL5519250 | 0.83 | KMT2A (0.53) | KMT2AFFAR2LMNAESR1ESR2 | |
| SCHEMBL2423106 | 0.83 | FFAR2 (0.64) | KMT2AL3MBTL1FFAR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9226922-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-05 | — | — | US | disclosed |
| US-20150258074-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150258074-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MAPK1, MAPK4, MAP3K20 | KMT2A 3123/4885ALOX5 4354/4885L3MBTL1 4253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.