Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17481195 | 0.78 | — | — | |
| SCHEMBL14549180 | 0.78 | — | — | |
| SCHEMBL11564103 | 0.76 | — | — | |
| SCHEMBL3186513 | 0.74 | — | — | |
| SCHEMBL5156148 | 0.74 | — | — | |
| SCHEMBL2170970 | 0.74 | — | — | |
| SCHEMBL17547305 | 0.74 | — | — | |
| SCHEMBL9501596 | 0.71 | MEN1 (0.34) | KDM4ESMN1; SMN2GAA | |
| SCHEMBL10968419 | 0.71 | — | — | |
| SCHEMBL5537146 | 0.71 | KDM4E (0.34) | KDM4EALDH1A1SMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170015671-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC | 2017-01-19 | — | — | US | disclosed |
| US-20160031891-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC | 2016-02-04 | — | — | US | disclosed |
| WO-2016019233-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-02-04 | — | — | WO | disclosed |
| US-9139954-B2 | Aqueous coloring composition for textile printing, textile printing method, and fabric | FUJIFILM CORPORATION (JP) | 2015-09-22 | — | — | US | disclosed |
| US-9139954-B2 | Aqueous coloring composition for textile printing, textile printing method, and fabric | FUJIFILM CORPORATION (JP) | 2015-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031891-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, SYK | KDM4E 1694/4885ALDH1A1 4709/4885SMN1; SMN2 4440/4885 |
| US-20170015671-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, SYK | KDM4E 1694/4885ALDH1A1 4709/4885SMN1; SMN2 4440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.