Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.54 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699066 | 1.00 | ALDH1A1 (0.54) | ALDH1A1CACNA1BAPBA1KMT2AMAPK1 | |
| SCHEMBL13915436 | 0.87 | ALDH1A1 (0.60) | ALDH1A1CACNA1BAPBA1KMT2AMAPK1 | |
| SCHEMBL6468293 | 0.82 | ALDH1A1 (0.51) | ALDH1A1CACNA1BAPBA1KMT2AMAPK1 | |
| SCHEMBL17017382 | 0.76 | HCRTR1 (0.72) | — | |
| SCHEMBL15830279 | 0.75 | PDE10A (0.58) | ALDH1A1CACNA1BAPBA1KMT2AMAPK1 | |
| SCHEMBL7694354 | 0.75 | ALDH1A1 (0.49) | ALDH1A1CACNA1BAPBA1KMT2AMAPK1 | |
| SCHEMBL16135782 | 0.75 | HRH3 (0.53) | ALDH1A1CACNA1BAPBA1KMT2AMAPK1 | |
| SCHEMBL17303977 | 0.74 | PDE10A (0.45) | ALDH1A1CACNA1BAPBA1KMT2AMAPK1 | |
| SCHEMBL17151389 | 0.74 | ALDH1A1 (0.48) | ALDH1A1CACNA1BAPBA1KMT2AMAPK1 | |
| SCHEMBL38650982 | 0.74 | PIM1 (0.40) | SYKKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088915-A1 | STEREOSELECTIVE METHODS, CATALYSTS AND INTERMEDIATES FOR THE SYNTHESIS OF (-)-NUTLIN-3 AND RELATED COMPOUNDS | VANDERBILT UNIVERSITY | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088915-A1 | STEREOSELECTIVE METHODS, CATALYSTS AND INTERMEDIATES FOR THE SYNTHESIS OF (-)-NUTLIN-3 AND RELATED COMPOUNDS | NUTF2, MDM2, CIAPIN1 | ALDH1A1 2092/4885CACNA1B 3641/4885APBA1 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.