Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 6/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11936200 | 0.91 | SLC22A12 (0.42) | CNR2CRHR1CNR1MCHR1ADRA2A | |
| SCHEMBL17090095 | 0.88 | EPHX2 (0.40) | EPHX2LMNAPOLBCRHR1BRD4 | |
| SCHEMBL11936203 | 0.85 | CNR2 (0.39) | LMNAPOLBCNR2CRHR1CNR1 | |
| SCHEMBL13565132 | 0.83 | NR1H4 (0.40) | BRD4 | |
| SCHEMBL13565478 | 0.83 | CRHR1 (0.40) | LMNAPOLBCNR2CRHR1BRD4 | |
| SCHEMBL13565482 | 0.83 | HDAC4 (0.41) | LMNACRHR1BRD4HCRTR1HCRTR2 | |
| SCHEMBL17090309 | 0.83 | HDAC4 (0.41) | LMNACRHR1BRD4HCRTR1HCRTR2 | |
| SCHEMBL17090319 | 0.83 | CRHR1 (0.40) | LMNAPOLBCNR2CRHR1BRD4 | |
| SCHEMBL17090000 | 0.83 | NR1H4 (0.40) | BRD4 | |
| SCHEMBL13565615 | 0.82 | F10 (0.37) | LMNAPOLBCNR2CRHR1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |