Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.36 |
| ▸ | BRD4 | O60885 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565174 | 1.00 | PTGER4 (0.36) | PTGER4GRIA2BRD4DRD2ADRA1D | |
| SCHEMBL13565307 | 0.88 | PTGER4 (0.35) | PTGER4GRIA2BRD4MKNK1MKNK2 | |
| SCHEMBL17090190 | 0.88 | PTGER4 (0.35) | PTGER4GRIA2BRD4MKNK1MKNK2 | |
| SCHEMBL17090189 | 0.85 | PDE4A (0.37) | PTGER4BRD4PDE4APDE4BPDE4C | |
| SCHEMBL13565127 | 0.85 | PDE4A (0.37) | PTGER4BRD4PDE4APDE4BPDE4C | |
| SCHEMBL13204432 | 0.83 | GSK3A (0.38) | GRIA2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10114950 | 0.83 | GSK3A (0.38) | GRIA2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13564939 | 0.82 | ACACB (0.39) | PTGER4GRIA2BRD4NPY5R | |
| SCHEMBL17090034 | 0.82 | ACACB (0.39) | PTGER4GRIA2BRD4NPY5R | |
| SCHEMBL11941027 | 0.80 | GRIA2 (0.38) | GRIA2BRD4DRD2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |