Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565099 | 1.00 | KDM4E (0.38) | KDM4ELMNAL3MBTL1BRD4CRHBP | |
| SCHEMBL13565888 | 0.89 | KDM4E (0.40) | KDM4ELMNAL3MBTL1BRD4CRHBP | |
| SCHEMBL17090292 | 0.88 | L3MBTL1 (0.33) | L3MBTL1BRD4CRHBPCRHR2PARP1 | |
| SCHEMBL13565508 | 0.86 | MAPT (0.37) | KDM4ELMNAL3MBTL1BRD4CRHBP | |
| SCHEMBL13565361 | 0.86 | MAPT (0.37) | KDM4ELMNAL3MBTL1BRD4CRHBP | |
| SCHEMBL17090286 | 0.86 | KDM4E (0.38) | KDM4ELMNAL3MBTL1CRHBPCRHR2 | |
| SCHEMBL13566018 | 0.86 | KDM4E (0.40) | KDM4ELMNAL3MBTL1BRD4CRHBP | |
| SCHEMBL13566037 | 0.86 | KDM4E (0.38) | KDM4ELMNAL3MBTL1CRHBPCRHR2 | |
| SCHEMBL13565266 | 0.86 | KDM4E (0.40) | KDM4ELMNAL3MBTL1BRD4CRHBP | |
| SCHEMBL13564991 | 0.86 | KDM4E (0.40) | KDM4ELMNAL3MBTL1BRD4CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |