Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.42 |
| ▸ | P2RY1 | P47900 | 7/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565603 | 1.00 | MAPT (0.46) | MAPTHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13565874 | 0.88 | MAPT (0.46) | MAPTHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13203773 | 0.83 | MAPT (0.54) | MAPTHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10133358 | 0.83 | MAPT (0.54) | MAPTHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13438694 | 0.82 | MAPT (0.50) | MAPTHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11934828 | 0.82 | MAPT (0.50) | MAPTHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13438991 | 0.80 | CNR2 (0.49) | SLC6A3CNR2CNR1 | |
| SCHEMBL11935299 | 0.80 | CNR2 (0.49) | SLC6A3CNR2CNR1 | |
| SCHEMBL13565656 | 0.77 | MAPT (0.49) | MAPTHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11935231 | 0.76 | CNR2 (0.43) | CRHR1CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |