Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | P2RY1 | P47900 | 7/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17089980 | 0.86 | MAPT (0.49) | MAPTP2RY1CARM1MAPK8PRMT6 | |
| SCHEMBL10113525 | 0.86 | MAPT (0.55) | MAPTP2RY1CARM1PRMT6 | |
| SCHEMBL11934973 | 0.83 | MAPT (0.54) | MAPTP2RY1CARM1PRMT6HTR1A | |
| SCHEMBL13565231 | 0.78 | PKM (0.41) | MAPTPOLB | |
| SCHEMBL17090481 | 0.77 | MAPT (0.46) | MAPTP2RY1CARM1PRMT6HTR1A | |
| SCHEMBL13565603 | 0.77 | MAPT (0.46) | MAPTP2RY1CARM1PRMT6HTR1A | |
| SCHEMBL11935545 | 0.73 | L3MBTL1 (0.43) | MAPTPOLBCYP2C9CYP2C19 | |
| SCHEMBL10113797 | 0.73 | MAPT (0.55) | MAPTP2RY1CARM1PRMT6 | |
| SCHEMBL13113420 | 0.72 | MAPT (0.64) | MAPTP2RY1CARM1PRMT6HTR1A | |
| SCHEMBL13565628 | 0.71 | HTR1A (0.56) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |