Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 18/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17091608 | 0.78 | PDE4D (0.40) | PARP1PDE4D | |
| SCHEMBL1289698 | 0.74 | ESR1 (0.60) | NOTUM | |
| SCHEMBL17091593 | 0.74 | NOTUM (0.48) | NOTUMPARP1PDE4D | |
| SCHEMBL17091609 | 0.73 | PDE4D (0.40) | PARP1PDE4D | |
| SCHEMBL564494 | 0.72 | PARP1 (0.58) | PARP1PDE4D | |
| SCHEMBL29729655 | 0.72 | PARP1 (0.58) | PARP1PDE4D | |
| SCHEMBL10049513 | 0.71 | PLAU (0.58) | PARP1PDE4D | |
| SCHEMBL6662996 | 0.71 | METAP2 (0.49) | PARP1PDE4D | |
| SCHEMBL6431677 | 0.71 | PARP1 (0.57) | PARP1PDE4D | |
| SCHEMBL29040612 | 0.71 | PARP1 (0.57) | PARP1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2624695-B1 | NOVEL SUBSTITUTED QUINOLINE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | NIVALIS THERAPEUTICS INC (US) | 2015-09-23 | — | — | EP | claimed |