Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.66 |
| ▸ | DRD3 | P35462 | 10/20 | 0.51 |
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709228 | 0.94 | SCN9A (0.69) | SCN9ADRD3DRD2NR4A1ESR2 | |
| SCHEMBL1709219 | 0.85 | SCN9A (0.74) | SCN9A | |
| SCHEMBL1709222 | 0.81 | SCN9A (0.60) | SCN9A | |
| SCHEMBL10072168 | 0.80 | SCN9A (0.56) | SCN9A | |
| SCHEMBL1286795 | 0.80 | SCN9A (1.00) | SCN9A | |
| SCHEMBL1709226 | 0.80 | SCN9A (1.00) | SCN9A | |
| SCHEMBL20918155 | 0.77 | SCN9A (0.49) | SCN9ADRD3DRD2 | |
| SCHEMBL20918157 | 0.77 | SCN9A (0.49) | SCN9ADRD3DRD2 | |
| SCHEMBL22262734 | 0.77 | SCN9A (0.49) | SCN9ADRD3DRD2 | |
| SCHEMBL1286845 | 0.77 | SCN9A (0.66) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |