Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.69 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | PREP | P48147 | 4/20 | 0.43 |
| ▸ | FAP | Q12884 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709225 | 0.94 | SCN9A (0.66) | SCN9ADRD2DRD3PREPNR4A1 | |
| SCHEMBL1709219 | 0.82 | SCN9A (0.74) | SCN9AKDM4EALDH1A1LMNADRD4 | |
| SCHEMBL1286795 | 0.81 | SCN9A (1.00) | SCN9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL20918157 | 0.81 | SCN9A (0.49) | SCN9ADRD2DRD3KDM4E | |
| SCHEMBL22262734 | 0.81 | SCN9A (0.49) | SCN9ADRD2DRD3KDM4E | |
| SCHEMBL20918155 | 0.81 | SCN9A (0.49) | SCN9ADRD2DRD3KDM4E | |
| SCHEMBL1709244 | 0.77 | SCN9A (0.66) | SCN9ADRD2DRD3LMNANPSR1 | |
| SCHEMBL1709226 | 0.77 | SCN9A (1.00) | SCN9AKDM4EALDH1A1DRD4 | |
| SCHEMBL1709222 | 0.76 | SCN9A (0.60) | SCN9AALDH1A1LMNADRD4 | |
| SCHEMBL10072168 | 0.75 | SCN9A (0.56) | SCN9AKDM4EALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |