Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.59 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.58 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | GRK5 | P34947 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CCR8 | P51685 | 2/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PRKX | P51817 | 1/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15634802 | 0.88 | CCR8 (0.68) | FAAHS1PR5KMT2AMEN1CCR8 | |
| SCHEMBL15635404 | 0.88 | CCR8 (0.68) | FAAHS1PR5KMT2AMEN1CCR8 | |
| SCHEMBL17104843 | 0.87 | CCR8 (0.67) | FAAHS1PR5KMT2AMEN1CCR8 | |
| SCHEMBL17099393 | 0.86 | CCR8 (0.57) | S1PR5KMT2AMEN1CCR8KDM4E | |
| SCHEMBL17048455 | 0.85 | MEN1 (0.55) | S1PR5S1PR1PDGFRAGRK5CDK8 | |
| SCHEMBL17099425 | 0.85 | CCR8 (0.59) | FAAHS1PR5CCR8KDM4EALDH1A1 | |
| SCHEMBL17055983 | 0.85 | CCR8 (0.61) | FAAHKMT2AMEN1CCR8KDM4E | |
| SCHEMBL17099436 | 0.84 | NOTUM (0.64) | S1PR5S1PR1CCR8NOTUM | |
| SCHEMBL17099410 | 0.84 | CCR8 (0.55) | S1PR5KMT2AMEN1CCR8KDM4E | |
| SCHEMBL17099350 | 0.84 | KDM4E (0.62) | FAAHKMT2AMEN1CCR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676757-B2 | Heterocyclic compounds as NaV channel inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2017-06-13 | — | — | US | disclosed |
| US-20150266862-A1 | HETEROCYCLIC COMPOUNDS AS NAV CHANNEL INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266862-A1 | HETEROCYCLIC COMPOUNDS AS NAV CHANNEL INHIBITORS AND USES THEREOF | CACNA1B, CACNG6, SCN5A | FAAH 407/4885S1PR5 2295/4885S1PR1 3362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.