Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17441037 | 0.82 | SYK (0.42) | FGFR1CTNNB1WNT3ASYKF11 | |
| SCHEMBL17440610 | 0.81 | FGFR1 (0.41) | FGFR1CTNNB1WNT3AMAPK1HTR2B | |
| SCHEMBL6227388 | 0.77 | ALDH1A1 (0.53) | RAB9AALDH1A1KDM4ECYP3A4TSHR | |
| SCHEMBL17099553 | 0.76 | CTNNB1 (0.38) | CTNNB1WNT3ARAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2169327 | 0.76 | ALDH1A1 (0.41) | RAB9AALDH1A1KDM4ECYP3A4TSHR | |
| SCHEMBL6227310 | 0.74 | CYP2C19 (0.55) | HTR2BRAB9AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL17440608 | 0.74 | MAPK1 (0.40) | FGFR1CTNNB1WNT3AMAPK1HTR2B | |
| SCHEMBL17596974 | 0.72 | PIM1 (0.48) | FGFR1CTNNB1WNT3AMAPK1ROCK2 | |
| SCHEMBL2171309 | 0.71 | DCAF1 (0.36) | RAB9AALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL17593783 | 0.71 | PDE4D (0.45) | FGFR1CTNNB1WNT3ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015143376-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF CYSTIC FIBROSIS | NIVALIS THERAPEUTICS, INC. (US) | 2015-09-24 | — | — | WO | disclosed |