Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422040 | 0.90 | IKBKB (0.47) | IKBKBSCN9AKDM4EALDH1A1NPC1 | |
| SCHEMBL29668334 | 0.90 | IKBKB (0.47) | IKBKBSCN9AKDM4EALDH1A1NPC1 | |
| SCHEMBL27808756 | 0.89 | IKBKB (0.46) | IKBKBSCN9AKDM4EALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL14843117 | 0.89 | IKBKB (0.46) | IKBKBSCN9AKDM4EALDH1A1NPC1 | |
| Azetidine SCHEMBL8511575 | 0.81 | IKBKB (0.41) | IKBKBSCN9AKDM4EALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL14844844 | 0.80 | IKBKB (0.40) | IKBKBSCN9AKDM4EALDH1A1NPC1 | |
| SCHEMBL28088528 | 0.79 | IKBKB (0.39) | IKBKBSCN9AKDM4EALDH1A1NPC1 | |
| SCHEMBL29427872 | 0.78 | MGAM (0.50) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2337793 | 0.78 | MGAM (0.50) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10559629 | 0.77 | IKBKB (0.41) | IKBKBKDM4EALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11001581-B2 | Compounds which inhibit RNA polymerase, compositions including such compounds, and their use | The Johns Hopkins University and Lieber Institute, Inc. (US) | 2021-05-11 | — | — | US | disclosed |
| EP-3778600-A1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE | The Johns Hopkins University (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3119781-B1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE | UNIV JOHNS HOPKINS (US) | 2020-09-16 | — | — | EP | disclosed |
| US-20170081322-A1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE | THE JOHNS HOPKINS UNIVERSITY | 2017-03-23 | — | — | US | disclosed |
| EP-3119781-A1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE | The Johns Hopkins University (US) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015143293-A1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11001581-B2 | Compounds which inhibit RNA polymerase, compositions including such compounds, and their use | POLR2H, MED25, POLR1A | IKBKB 1456/4885SCN9A 3043/4885KDM4E 1551/4885 |
| US-20170081322-A1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE | POLR2H, MED25, POLR1A | IKBKB 1456/4885SCN9A 3043/4885KDM4E 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.