Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17102224 | 0.96 | HTR6 (0.42) | HTR6HTR2AHTR7TRPV1ALDH1A1 | |
| SCHEMBL17097217 | 0.89 | HTR6 (0.42) | HTR6HTR2AHTR7TRPV1ALDH1A1 | |
| SCHEMBL17097134 | 0.89 | IDO1 (0.50) | HTR6HTR2AHTR7TRPV1CA12 | |
| SCHEMBL17102242 | 0.87 | HTR6 (0.45) | HTR6HTR2AHTR7TRPV1POLB | |
| SCHEMBL17096764 | 0.86 | HTR6 (0.47) | HTR6HTR2AHTR7TRPV1 | |
| SCHEMBL17096726 | 0.86 | HTR6 (0.42) | HTR6HTR2AHTR7TRPV1ALDH1A1 | |
| SCHEMBL17097082 | 0.85 | HTR6 (0.46) | HTR6HTR2AHTR7TRPV1ALDH1A1 | |
| SCHEMBL17097305 | 0.84 | KDM4E (0.45) | HTR6HTR2AHTR7ALDH1A1CA12 | |
| SCHEMBL17097323 | 0.84 | HTR6 (0.49) | HTR6HTR2AHTR7DRD2MMP2 | |
| SCHEMBL17097214 | 0.84 | HTR6 (0.43) | HTR6HTR2AHTR7TRPV1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119763-A1 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Iteos Therapeutics (BE) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140717-A1 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | ITEOS THERAPEUTICS (BE) | 2015-09-24 | — | — | WO | disclosed |