Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1346010 | 0.81 | GPR84 (0.43) | KDM4EPKMHPGDALDH1A1HSD17B10 | |
| SCHEMBL29851170 | 0.80 | GPR84 (0.42) | KDM4EPKMHPGDALDH1A1HSD17B10 | |
| SCHEMBL31702536 | 0.79 | GPR84 (0.41) | KDM4EPKMHPGDALDH1A1HSD17B10 | |
| SCHEMBL14856834 | 0.79 | GPR84 (0.41) | KDM4EPKMHPGDALDH1A1HSD17B10 | |
| SCHEMBL10613388 | 0.75 | ELANE (0.42) | KDM4EPKMHPGDALDH1A1HSD17B10 | |
| SCHEMBL710654 | 0.74 | HPGD (0.58) | KDM4EPKMHPGDALDH1A1HSD17B10 | |
| SCHEMBL30026986 | 0.74 | HPGD (0.58) | KDM4EPKMHPGDALDH1A1HSD17B10 | |
| SCHEMBL11300207 | 0.74 | DAO (0.37) | KDM4EHPGDALDH1A1HSD17B10HTT | |
| SCHEMBL27458026 | 0.73 | MAPT (0.50) | KDM4EHPGDALDH1A1HSD17B10HTT | |
| SCHEMBL22043210 | 0.72 | GPR84 (0.36) | KDM4EPKMHPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344470-A1 | 3-AZABICYCLO[3.1.0]HEXYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Ortho-McNeil-Janssen Pharmaceuticals, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| EP-2203439-A1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1'H-Ý1, 4'¨BIPYRIDINYL-2'-ONES | Ortho-McNeil-Janssen Pharmaceuticals, Inc. (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2010025890-A1 | 3-AZABICYCLO[3.1.0]HEXYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2009033704-A1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1'H-[1, 4'] BIPYRIDINYL-2'-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |