Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.46 |
| ▸ | CTSK | P43235 | 7/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710629 | 0.83 | AR (0.41) | ARCTSKHAO1CRBNCYP1A2 | |
| SCHEMBL1722980 | 0.82 | AR (0.40) | ARCTSKHAO1CYP1A2CYP2E1 | |
| SCHEMBL1710302 | 0.82 | AR (0.40) | ARCTSKHAO1CYP1A2CYP2E1 | |
| SCHEMBL1722996 | 0.75 | CTSK (0.40) | ARCTSKCTSLHAO1CTSB | |
| SCHEMBL1710414 | 0.74 | CTSK (0.40) | ARCTSKCTSLHAO1CTSB | |
| SCHEMBL1710511 | 0.73 | CTSK (0.49) | ARCTSKCRBNKMT2A | |
| SCHEMBL13400233 | 0.73 | DDB1 (0.48) | ARCTSKCTSLHAO1CRBN | |
| SCHEMBL13400249 | 0.72 | CTSK (0.49) | ARCTSK | |
| SCHEMBL1710383 | 0.72 | CTSK (0.48) | ARCTSKCRBNKMT2A | |
| SCHEMBL13400234 | 0.72 | CTSK (0.48) | ARCTSKCRBNKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344451-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028088-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-03-11 | — | — | WO | disclosed |