Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 20/20 | 0.85 |
| ▸ | GABRP | O00591 | 2/20 | 0.78 |
| ▸ | GABRD | O14764 | 2/20 | 0.78 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.78 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.78 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.78 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.78 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.78 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.78 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.78 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.78 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.78 |
| ▸ | GABRE | P78334 | 2/20 | 0.78 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.78 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.78 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.78 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.78 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.78 |
| ▸ | PGR | P06401 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15661295 | 1.00 | AR (0.85) | ARGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL547539 | 0.99 | AR (0.87) | ARGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29861461 | 0.99 | AR (0.87) | ARGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL547156 | 0.98 | AR (0.87) | ARGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29378261 | 0.98 | AR (0.87) | ARGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL17107295 | 0.94 | AR (0.85) | ARGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL17117368 | 0.92 | AR (0.78) | ARGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL17107300 | 0.92 | AR (0.78) | ARGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL17117389 | 0.92 | AR (0.78) | ARGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL14930979 | 0.92 | AR (1.00) | ARGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11739069-B2 | Modulators of resistant androgen receptor | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2023-08-29 | — | — | US | disclosed |
| US-11739069-B2 | Modulators of resistant androgen receptor | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2023-08-29 | — | — | US | disclosed |
| EP-2911666-B1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2022-08-24 | — | — | EP | disclosed |
| US-20200172504-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2020-06-04 | — | — | US | disclosed |
| US-20200172504-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2020-06-04 | — | — | US | disclosed |
| US-10450294-B2 | Modulators of resistant androgen receptor | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2019-10-22 | — | — | US | disclosed |
| US-10450294-B2 | Modulators of resistant androgen receptor | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2019-10-22 | — | — | US | disclosed |
| EP-2912194-B1 | ANDROGEN RECEPTOR VARIANTS AND METHODS FOR MAKING AND USING | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2019-05-08 | — | — | EP | disclosed |
| US-10206911-B2 | Androgen receptor variants and methods for making and using | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2019-02-19 | — | — | US | disclosed |
| US-20170320849-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2017-11-09 | — | — | US | disclosed |
| US-20170320849-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2017-11-09 | — | — | US | disclosed |
| US-9650359-B2 | Modulators of resistant androgen receptor | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2017-05-16 | — | — | US | disclosed |
| US-9650359-B2 | Modulators of resistant androgen receptor | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2017-05-16 | — | — | US | disclosed |
| US-20160257666-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2016-09-08 | — | — | US | disclosed |
| US-20160257666-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2016-09-08 | — | — | US | disclosed |
| US-9365542-B2 | Modulators of resistant androgen receptor | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2016-06-14 | — | — | US | disclosed |
| US-9365542-B2 | Modulators of resistant androgen receptor | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2016-06-14 | — | — | US | disclosed |
| US-20150274693-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-01 | — | — | US | disclosed |
| US-20150274693-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-01 | — | — | US | disclosed |
| US-20150265587-A1 | ANDROGEN RECEPTOR VARIANTS AND METHODS FOR MAKING AND USING | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150265587-A1 | ANDROGEN RECEPTOR VARIANTS AND METHODS FOR MAKING AND USING | AR, NR5A1, NR3C2 | AR 1/4885GABRP 2507/4885GABRD 2427/4885 |
| US-10206911-B2 | Androgen receptor variants and methods for making and using | AR, NR5A1, NR3C2 | AR 1/4885GABRP 2507/4885GABRD 2427/4885 |
| US-11739069-B2 | Modulators of resistant androgen receptor | AR, NR5A1, ESRRA | AR 1/4885GABRP 256/4885GABRD 179/4885 |
| US-20160257666-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | AR, NR5A1, ESRRA | AR 1/4885GABRP 256/4885GABRD 179/4885 |
| US-20200172504-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | AR, NR5A1, ESRRA | AR 1/4885GABRP 256/4885GABRD 179/4885 |
| US-20170320849-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | AR, NR5A1, ESRRA | AR 1/4885GABRP 256/4885GABRD 179/4885 |
| US-20150274693-A1 | MODULATORS OF RESISTANT ANDROGEN RECEPTOR | AR, NR5A1, ESRRA | AR 1/4885GABRP 396/4885GABRD 298/4885 |
| US-10450294-B2 | Modulators of resistant androgen receptor | AR, NR5A1, ESRRA | AR 1/4885GABRP 256/4885GABRD 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.