SCHEMBL547156

SCHEMBL547156

CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1F

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 20/20 0.87
GABRP O00591 2/20 0.79
GABRD O14764 2/20 0.79
GABRA1 P14867 2/20 0.79
GABRB1 P18505 2/20 0.79
GABRG2 P18507 2/20 0.79
GABRB3 P28472 2/20 0.79
GABRA5 P31644 2/20 0.79
GABRA3 P34903 2/20 0.79
GABRA2 P47869 2/20 0.79
GABRB2 P47870 2/20 0.79
GABRA4 P48169 2/20 0.79
GABRE P78334 2/20 0.79
GABRA6 Q16445 2/20 0.79
GABRG1 Q8N1C3 2/20 0.79
GABRG3 Q99928 2/20 0.79
GABRQ Q9UN88 2/20 0.79
NR3C1 P04150 2/20 0.79
NR1I2 O75469 1/20 0.79
PGR P06401 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29378261 1.00 AR (0.87) ARGABRPGABRDGABRA1GABRB1
SCHEMBL547539 0.98 AR (0.87) ARGABRPGABRDGABRA1GABRB1
SCHEMBL29861461 0.98 AR (0.87) ARGABRPGABRDGABRA1GABRB1
SCHEMBL15661295 0.98 AR (0.85) ARGABRPGABRDGABRA1GABRB1
SCHEMBL17107302 0.98 AR (0.85) ARGABRPGABRDGABRA1GABRB1
SCHEMBL17107300 0.95 AR (0.78) ARGABRPGABRDGABRA1GABRB1
SCHEMBL17117389 0.95 AR (0.78) ARGABRPGABRDGABRA1GABRB1
SCHEMBL17117368 0.95 AR (0.78) ARGABRPGABRDGABRA1GABRB1
SCHEMBL17107295 0.94 AR (0.85) ARGABRPGABRDGABRA1GABRB1
SCHEMBL14930979 0.93 AR (1.00) ARGABRPGABRDGABRA1GABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 166 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50642-E1 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2025-10-21 US claimed
US-RE49353-E1 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2023-01-03 US claimed
US-20220160695-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER ARAGON PHARMACEUTICALS, INC. 2022-05-26 US claimed
EP-3917519-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER Aragon Pharmaceuticals, Inc. (US) 2021-12-08 EP claimed
WO-2020157699-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER ARAGON PHARMACEUTICALS, INC. (US) 2020-08-06 WO claimed
EP-3610876-A1 ANTI-ANDROGENS IN COMBINATION WITH ABIRATERONE ACETATE AND PREDNISONE FOR TREATING PROSTATE CANCER Aragon Pharmaceuticals, Inc. (US) 2020-02-19 EP claimed
US-20180318277-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2018-11-08 US claimed
US-10052314-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2018-08-21 US claimed
US-20180110764-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2018-04-26 US claimed
EP-3305285-A1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER Aragon Pharmaceuticals, Inc. (US) 2018-04-11 EP claimed
US-9884054-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2018-02-06 US claimed
EP-2900224-A1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER Aragon Pharmaceuticals, Inc. (US) 2015-08-05 EP claimed
US-20140088129-A1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER ARAGON PHARMACEUTICALS, INC. (US) 2014-03-27 US claimed
US-20130034501-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-02-07 US claimed
EP-1893196-A4 DIARYLHYDANTOIN COMPOUNDS UNIV CALIFORNIA (US) 2009-03-18 EP claimed
JP-2008540523-A 2008-11-20 JP claimed
EP-1893196-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-03-05 EP claimed
US-20070004753-A1 N-methyl-4-{4-[7-(4-cyano-3 -trifluoromethylphenyl)-6,8-dioxo-5,7-diazaspiro[3.4]oct-5-yl]-phenyl}butyramide; for treatment of hormone refractory prostate cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-01-04 US claimed
WO-2006124118-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-11-23 WO claimed
US-20250333385-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-10-30 US disclosed
US-RE50642-E1 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2025-10-21 US disclosed
US-12303497-B2 Anti-androgens for the treatment of metastatic castration-sensitive prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2025-05-20 US disclosed
US-20240165091-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER ARAGON PHARMACEUTICALS INC (US) 2024-05-23 US disclosed
US-20240132452-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-04-25 US disclosed
US-11963952-B2 Anti-androgens for the treatment of metastatic castration-sensitive prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2024-04-23 US disclosed
US-11903937-B2 2024-02-20 US disclosed
US-20230405094-A1 TREATMENT OR PREVENTION OF A DISEASE OR DISORDER Janssen Sciences Ireland Unlimited Company (IE) 2023-12-21 US disclosed
US-20230338351-A1 Androgen Receptor Inhibitors For The Treatment Of Non-Metastatic Castration-Resistant Prostate Cancer In Subjects With Severe Hepatic Impairment ARAGON PHARMACEUTICALS INC (US) 2023-10-26 US disclosed
US-20230338351-A1 Androgen Receptor Inhibitors For The Treatment Of Non-Metastatic Castration-Resistant Prostate Cancer In Subjects With Severe Hepatic Impairment ARAGON PHARMACEUTICALS INC (US) 2023-10-26 US disclosed
EP-3357513-B1 PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF KANGPU BIOPHARMACEUTICALS LTD (CN) 2023-10-25 EP disclosed
EP-4247333-A1 TREATMENT OR PREVENTION OF A DISEASE OR DISORDER Janssen Sciences Ireland Unlimited Company (IE) 2023-09-27 EP disclosed
US-11723898-B2 Androgen receptor inhibitors for the treatment of non-metastatic castration-resistant prostate cancer in subjects with severe hepatic impairment ARAGON PHARMACEUTICALS, INC. (US) 2023-08-15 US disclosed
US-11723898-B2 Androgen receptor inhibitors for the treatment of non-metastatic castration-resistant prostate cancer in subjects with severe hepatic impairment ARAGON PHARMACEUTICALS, INC. (US) 2023-08-15 US disclosed
US-20230190722-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER ARAGON PHARMACEUTICALS INC (US) 2023-06-22 US disclosed
US-20230190722-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER ARAGON PHARMACEUTICALS INC (US) 2023-06-22 US disclosed
US-20230109968-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-04-13 US disclosed
US-20230014124-A1 HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION C4 THERAPEUTICS, INC. (US) 2023-01-19 US disclosed
US-RE49353-E1 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2023-01-03 US disclosed
US-RE49353-E1 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2023-01-03 US disclosed
EP-4054572-A1 ANDROGEN RECEPTOR INHIBITORS FOR THE TREATMENT OF NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER IN SUBJECTS WITH SEVERE HEPATIC IMPAIRMENT Aragon Pharmaceuticals, Inc. (US) 2022-09-14 EP disclosed
WO-2022106487-A1 TREATMENT OR PREVENTION OF A DISEASE OR DISORDER Janssen Sciences Ireland Unlimited Company (IE) 2022-05-27 WO disclosed
US-20220160695-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER ARAGON PHARMACEUTICALS, INC. 2022-05-26 US disclosed
US-20220160695-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER ARAGON PHARMACEUTICALS, INC. 2022-05-26 US disclosed
EP-3970721-A1 DIARYLHYDANTOIN COMPOUNDS AS ANDROGEN RECEPTOR ANTAGONISTS FOR TREATMENT OF CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-03-23 EP disclosed
EP-3917519-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER Aragon Pharmaceuticals, Inc. (US) 2021-12-08 EP disclosed
US-11185592-B2 Spirocyclic degronimers for target protein degradation C4 THERAPEUTICS, INC. (US) 2021-11-30 US disclosed
US-20210238145-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-08-05 US disclosed
US-20210238145-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-08-05 US disclosed
EP-3527210-B1 COMBINED COMPOSITION COMPRISING A BENZOHETEROCYCLIC COMPOUND AND AN ANDROGEN RECEPTOR PATHWAY MODULATOR AND USES THEREOF KANGPU BIOPHARMACEUTICALS LTD (CN) 2021-06-09 EP disclosed
US-20210128541-A1 ANDROGEN RECEPTOR INHIBITORS FOR THE TREATMENT OF NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER IN SUBJECTS WITH SEVERE HEPATIC IMPAIRMENT ARAGON PHARMACEUTICALS, INC. 2021-05-06 US disclosed
US-20210128541-A1 ANDROGEN RECEPTOR INHIBITORS FOR THE TREATMENT OF NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER IN SUBJECTS WITH SEVERE HEPATIC IMPAIRMENT ARAGON PHARMACEUTICALS, INC. 2021-05-06 US disclosed
US-20210113545-A1 Pharmaceutical Composition Comprising a Benzoheterocyclic Compound and Androgen Receptor Pathway Modulator and Application Thereof KANGPU BIOPHARMACEUTICALS LTD (CN) 2021-04-22 US disclosed
US-20210106688-A1 SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION C4 THERAPEUTICS, INC. (US) 2021-04-15 US disclosed
US-20210069154-A1 Treatment of Breast Cancer MEDIVATION PROSTATE THERAPEUTICS LLC 2021-03-11 US disclosed
US-10933059-B2 Combination, application thereof and treatment method KANGPU BIOPHARMACEUTICALS. LTD. (CN) 2021-03-02 US disclosed
EP-3777845-A1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER Aragon Pharmaceuticals, Inc. (US) 2021-02-17 EP disclosed
EP-3777845-A1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER Aragon Pharmaceuticals, Inc. (US) 2021-02-17 EP disclosed
US-10905768-B1 Heterocyclic degronimers for target protein degradation C4 THERAPEUTICS, INC. (US) 2021-02-02 US disclosed
US-20210000812-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2021-01-07 US disclosed
US-20210000812-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2021-01-07 US disclosed
US-10849888-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2020-12-01 US disclosed
US-10849888-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2020-12-01 US disclosed
US-20200354334-A1 Process For The Preparation Of A Diarylthiohydantoin Compound ARAGON PHARMACEUTICALS INC (US) 2020-11-12 US disclosed
US-10799489-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2020-10-13 US disclosed
US-10799489-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2020-10-13 US disclosed
US-10799488-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2020-10-13 US disclosed
US-10799488-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2020-10-13 US disclosed
EP-3305285-B1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER ARAGON PHARMACEUTICALS INC (US) 2020-09-02 EP disclosed
WO-2020157699-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER ARAGON PHARMACEUTICALS, INC. (US) 2020-08-06 WO disclosed
US-20200079741-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-03-12 US disclosed
US-20190328722-A1 COMBINATION, APPLICATION THEREOF AND TREATMENT METHOD KANGPU BIOPHARMACEUTICALS, LTD. (CN) 2019-10-31 US disclosed
US-20190269667-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2019-09-05 US disclosed
US-20190269667-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2019-09-05 US disclosed
US-20190269668-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2019-09-05 US disclosed
US-20190269668-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2019-09-05 US disclosed
US-20190262315-A1 Treatment of Breast Cancer MEDIVATION PROSTATE THERAPEUTICS, INC. 2019-08-29 US disclosed
EP-3527210-A1 COMPOSITION, APPLICATION THEREOF AND TREATMENT METHOD Kangpu Biopharmaceuticals, Ltd. (CN) 2019-08-21 EP disclosed
US-20190210974-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-07-11 US disclosed
US-20190210974-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-07-11 US disclosed
US-20180318277-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2018-11-08 US disclosed
US-10052314-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2018-08-21 US disclosed
EP-3357513-A1 PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Kangpu Biopharmaceuticals, Ltd. (CN) 2018-08-08 EP disclosed
US-20180110764-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2018-04-26 US disclosed
US-20180110764-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer ARAGON PHARMACEUTICALS INC (US) 2018-04-26 US disclosed
EP-3305285-A1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER Aragon Pharmaceuticals, Inc. (US) 2018-04-11 EP disclosed
US-20180086718-A1 Diarylhydantoin Compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-03-29 US disclosed
US-20180086718-A1 Diarylhydantoin Compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-03-29 US disclosed
US-20180055915-A1 COMPOSITIONS AND METHODS FOR TREATING PROSTATE CANCER NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2018-03-01 US disclosed
US-20180055915-A1 COMPOSITIONS AND METHODS FOR TREATING PROSTATE CANCER NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2018-03-01 US disclosed
US-9884054-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2018-02-06 US disclosed
US-9884054-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer ARAGON PHARMACEUTICALS, INC. (US) 2018-02-06 US disclosed
US-20170101384-A1 ANDROGEN RECEPTOR ANTAGONISTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2017-04-13 US disclosed
US-20170087132-A1 Treatment of Breast Cancer MEDIVATION PROSTATE THERAPEUTICS LLC 2017-03-30 US disclosed
EP-3106162-A1 DIARYLHYDANTOIN COMPOUNDS AS ANDROGEN RECEPTOR ANTAGONISTS FOR TREATMENT OF CANCER The Regents of the University of California (US) 2016-12-21 EP disclosed
EP-3106162-A1 DIARYLHYDANTOIN COMPOUNDS AS ANDROGEN RECEPTOR ANTAGONISTS FOR TREATMENT OF CANCER The Regents of the University of California (US) 2016-12-21 EP disclosed
US-9517229-B2 Treatment of breast cancer MEDIVATION PROSTATE THERAPEUTICS, INC. (US) 2016-12-13 US disclosed
EP-2792674-B1 IMIDAZOLIDINEDIONE COMPOUNDS AND THEIR USES HINOVA PHARMACEUTICAL INC (CN) 2016-05-25 EP disclosed
US-9346764-B2 Imidazolidinedione compounds and their uses HINOVA PHARMACEUTICALS INC. (CN) 2016-05-24 US disclosed
EP-3020706-A1 DIARYLTHIOHYDANTOIN COMPOUNDS USEFUL FOR THE TREATMENT OF A HYPERPROLIFERATIVE DISORDER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-05-18 EP disclosed
EP-3020706-A1 DIARYLTHIOHYDANTOIN COMPOUNDS USEFUL FOR THE TREATMENT OF A HYPERPROLIFERATIVE DISORDER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-05-18 EP disclosed
WO-2015196144-A2 ANDROGEN RECEPTOR ANTAGONISTS ENGLAND PAMELA M (US) 2015-12-23 WO disclosed
US-9205102-B2 Method for treatment of castration-resistant prostate cancer THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2015-12-08 US disclosed
US-9126941-B2 Treatment of hyperproliferative disorders with diarylhydantoin compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-09-08 US disclosed
US-9126941-B2 Treatment of hyperproliferative disorders with diarylhydantoin compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-09-08 US disclosed
EP-2900224-A1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER Aragon Pharmaceuticals, Inc. (US) 2015-08-05 EP disclosed
EP-1893196-B2 DIARYLHYDANTOIN COMPOUND UNIV CALIFORNIA (US) 2015-07-29 EP disclosed
EP-1893196-B2 DIARYLHYDANTOIN COMPOUND UNIV CALIFORNIA (US) 2015-07-29 EP disclosed
US-20150157656-A1 Method for Treatment of Castration-Resistant Prostate Cancer THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2015-06-11 US disclosed
US-20150112082-A1 DIARYLHYDANTOIN COMPOUNDS HOWARD HUGHES MEDICAL INSTITUTE 2015-04-23 US disclosed
US-20150112082-A1 DIARYLHYDANTOIN COMPOUNDS HOWARD HUGHES MEDICAL INSTITUTE 2015-04-23 US disclosed
EP-2444085-B1 Diarylhydantoin compounds as androgen receptor antagonists for treatment of cancer UNIV CALIFORNIA (US) 2015-03-18 EP disclosed
EP-2444085-B1 Diarylhydantoin compounds as androgen receptor antagonists for treatment of cancer UNIV CALIFORNIA (US) 2015-03-18 EP disclosed
US-20140371284-A1 IMIDAZOLIDINEDIONE COMPOUNDS AND THEIR USES HC PHARMACEUTICAL CO., LTD. (CN) 2014-12-18 US disclosed
US-20140343111-A1 DIARYLTHIOHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-11-20 US disclosed
US-20140343111-A1 DIARYLTHIOHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-11-20 US disclosed
EP-2013187-B1 DIARYLTHIOHYDANTOIN COMPOUNDS UNIV CALIFORNIA (US) 2014-10-29 EP disclosed
EP-2792674-A1 IMIDAZOLIDINEDIONE COMPOUNDS AND THEIR USES HC Pharmaceutical Co., Ltd. (CN) 2014-10-22 EP disclosed
US-20140296312-A1 TREATMENT OF BREAST CANCER THE REGENTS OF THE UNIVERSITY OF COLORADO (US) 2014-10-02 US disclosed
US-20140088129-A1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER ARAGON PHARMACEUTICALS, INC. (US) 2014-03-27 US disclosed
US-20140088129-A1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER ARAGON PHARMACEUTICALS, INC. (US) 2014-03-27 US disclosed
US-8658681-B2 2014-02-25 US disclosed
US-8658681-B2 2014-02-25 US disclosed
US-8648105-B2 Diarylthiohydantoin compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-02-11 US disclosed
US-8648105-B2 Diarylthiohydantoin compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-02-11 US disclosed
US-20140031409-A1 METHODS FOR TREATING ANDROGEN RECEPTOR DEPENDENT DISORDERS INCLUDING CANCERS SANTARIS PHARMA A/S (DK) 2014-01-30 US disclosed
WO-2013066440-A9 TREATMENT OF BREAST CANCER MEDIVATION PROSTATE THERAPEUTICS, INC. (US) 2013-07-18 WO disclosed
US-8450290-B2 Methods for treating androgen receptor dependent disorders including cancers ENZON PHARMACEUTICALS, INC. (US) 2013-05-28 US disclosed
WO-2013066440-A1 TREATMENT OF BREAST CANCER MEDIVATION PROSTATE THERAPEUTICS, INC. (US) 2013-05-10 WO disclosed
EP-2561871-A1 Diarylhydantoin compounds as androgen receptor antagonists for treatment of cancer The Regents of The University of California (US) 2013-02-27 EP disclosed
EP-2561871-A1 Diarylhydantoin compounds as androgen receptor antagonists for treatment of cancer The Regents of The University of California (US) 2013-02-27 EP disclosed
US-20130034501-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-02-07 US disclosed
US-20130034501-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-02-07 US disclosed
US-20120295944-A1 TREATMENT OF HYPERPROLIFERATIVE DISORDERS WITH DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-11-22 US disclosed
US-20120295944-A1 TREATMENT OF HYPERPROLIFERATIVE DISORDERS WITH DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-11-22 US disclosed
US-20120190718-A1 DIARYLTHIOHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-07-26 US disclosed
US-20120190718-A1 DIARYLTHIOHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-07-26 US disclosed
US-8183274-B2 Treatment of hyperproliferative disorders with diarylhydantoin compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-05-22 US disclosed
US-8183274-B2 Treatment of hyperproliferative disorders with diarylhydantoin compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-05-22 US disclosed
WO-2012065051-A1 COMPOSITIONS AND METHODS FOR TREATING ANDROGEN RECEPTOR DEPENDENT DISORDERS INCLUDING CANCERS ENZON PHARMACEUTICALS, INC. (US) 2012-05-18 WO disclosed
EP-2444085-A1 Diarylhydantoin compounds as androgen receptor antagonists for treatment of cancer The Regents of The University of California (US) 2012-04-25 EP disclosed
EP-2444085-A1 Diarylhydantoin compounds as androgen receptor antagonists for treatment of cancer The Regents of The University of California (US) 2012-04-25 EP disclosed
US-8110594-B2 Diarylthiohydantoin compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-07 US disclosed
US-8110594-B2 Diarylthiohydantoin compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-07 US disclosed
EP-1893196-B1 DIARYLHYDANTOIN COMPOUND UNIV CALIFORNIA (US) 2012-01-18 EP disclosed
EP-1893196-B1 DIARYLHYDANTOIN COMPOUND UNIV CALIFORNIA (US) 2012-01-18 EP disclosed
US-20110152348-A1 METHODS FOR TREATING ANDROGEN RECEPTOR DEPENDENT DISORDERS INCLUDING CANCERS ENZON PHARMACEUTICALS, INC. (US) 2011-06-23 US disclosed
US-20100210665-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-08-19 US disclosed
US-20100210665-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-08-19 US disclosed
US-20100172975-A1 TREATMENT OF HYPERPROLIFERATIVE DISORDERS WITH DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-07-08 US disclosed
US-20100172975-A1 TREATMENT OF HYPERPROLIFERATIVE DISORDERS WITH DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-07-08 US disclosed
US-7709517-B2 N-methyl-4-{4-[7-(4-cyano-3 -trifluoromethylphenyl)-6,8-dioxo-5,7-diazaspiro[3.4]oct-5-yl]-phenyl}butyramide; for treatment of hormone refractory prostate cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-05-04 US disclosed
US-7709517-B2 N-methyl-4-{4-[7-(4-cyano-3 -trifluoromethylphenyl)-6,8-dioxo-5,7-diazaspiro[3.4]oct-5-yl]-phenyl}butyramide; for treatment of hormone refractory prostate cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-05-04 US disclosed
EP-1893196-A4 DIARYLHYDANTOIN COMPOUNDS UNIV CALIFORNIA (US) 2009-03-18 EP disclosed
EP-2013187-A2 DIARYLTHIOHYDANTOIN COMPOUNDS The Regents of the University of California (US) 2009-01-14 EP disclosed
US-20080139634-A2 Use against hormone refractory prostate cancer; 1-(3-trifluoromethyl-4-cyanophenyl)-2-thioxo-3-(substituted phenyl)-imidazolidin-5-one and spiro ring derivatives thereof; androgen receptor antagonists with minimal agonist activity REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-06-12 US disclosed
US-20080139634-A2 Use against hormone refractory prostate cancer; 1-(3-trifluoromethyl-4-cyanophenyl)-2-thioxo-3-(substituted phenyl)-imidazolidin-5-one and spiro ring derivatives thereof; androgen receptor antagonists with minimal agonist activity REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-06-12 US disclosed
WO-2007127010-A9 DIARYLTHIOHYDANTOIN COMPOUNDS UNIV CALIFORNIA (US) 2008-05-22 WO disclosed
WO-2007127010-A9 DIARYLTHIOHYDANTOIN COMPOUNDS UNIV CALIFORNIA (US) 2008-05-22 WO disclosed
EP-1893196-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-03-05 EP disclosed
WO-2007127010-A2 DIARYLTHIOHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-11-08 WO disclosed
WO-2007127010-A2 DIARYLTHIOHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-11-08 WO disclosed
US-20070254933-A1 Use against hormone refractory prostate cancer; 1-(3-trifluoromethyl-4-cyanophenyl)-2-thioxo-3-(substituted phenyl)-imidazolidin-5-one and spiro ring derivatives thereof; selective androgen receptor modulators; non-steroidal, non-toxic, and tissue selective REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-11-01 US disclosed
US-20070254933-A1 Use against hormone refractory prostate cancer; 1-(3-trifluoromethyl-4-cyanophenyl)-2-thioxo-3-(substituted phenyl)-imidazolidin-5-one and spiro ring derivatives thereof; selective androgen receptor modulators; non-steroidal, non-toxic, and tissue selective REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-11-01 US disclosed
US-20070004753-A1 N-methyl-4-{4-[7-(4-cyano-3 -trifluoromethylphenyl)-6,8-dioxo-5,7-diazaspiro[3.4]oct-5-yl]-phenyl}butyramide; for treatment of hormone refractory prostate cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-01-04 US disclosed
US-20070004753-A1 N-methyl-4-{4-[7-(4-cyano-3 -trifluoromethylphenyl)-6,8-dioxo-5,7-diazaspiro[3.4]oct-5-yl]-phenyl}butyramide; for treatment of hormone refractory prostate cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-01-04 US disclosed
WO-2006124118-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-11-23 WO disclosed
WO-2006124118-A1 DIARYLHYDANTOIN COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-11-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (50 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10799489-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer AR, SHBG, KLK3 AR 1/4885GABRP 2633/4885GABRD 2171/4885
US-20190328722-A1 COMBINATION, APPLICATION THEREOF AND TREATMENT METHOD CYP21A2, CYP17A1, NR5A1 AR 5/4885GABRP 840/4885GABRD 639/4885
US-20110152348-A1 METHODS FOR TREATING ANDROGEN RECEPTOR DEPENDENT DISORDERS INCLUDING CANCERS AR, ESRRB, ESRRA AR 1/4885GABRP 820/4885GABRD 277/4885
US-20180110764-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer AR, SHBG, KLK3 AR 1/4885GABRP 2633/4885GABRD 2171/4885
US-20240132452-A1 DIARYLHYDANTOIN COMPOUNDS BPHL, AR, SHBG AR 2/4885GABRP 4199/4885GABRD 3464/4885
US-20210113545-A1 Pharmaceutical Composition Comprising a Benzoheterocyclic Compound and Androgen Receptor Pathway Modulator and Application Thereof AR, NR5A1, CYP17A1 AR 1/4885GABRP 496/4885GABRD 481/4885
US-20140088129-A1 ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC CASTRATE-RESISTANT PROSTATE CANCER AR, SHBG, KLK3 AR 1/4885GABRP 2633/4885GABRD 2171/4885
US-20120295944-A1 TREATMENT OF HYPERPROLIFERATIVE DISORDERS WITH DIARYLHYDANTOIN COMPOUNDS CDK4, CCNH, VHL AR 113/4885GABRP 4700/4885GABRD 3973/4885
US-20080139634-A2 Use against hormone refractory prostate cancer; 1-(3-trifluoromethyl-4-cyanophenyl)-2-thioxo-3-(substituted phenyl)-imidazolidin-5-one and spiro ring derivatives thereof; androgen receptor antagonists with minimal agonist activity AR, LHCGR, KLK3 AR 1/4885GABRP 1272/4885GABRD 1538/4885
US-20070254933-A1 Use against hormone refractory prostate cancer; 1-(3-trifluoromethyl-4-cyanophenyl)-2-thioxo-3-(substituted phenyl)-imidazolidin-5-one and spiro ring derivatives thereof; selective androgen receptor modulators; non-steroidal, non-toxic, and tissue selective AR, NR5A1, SHBG AR 1/4885GABRP 1935/4885GABRD 2045/4885
US-20230014124-A1 HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION CRBN, MDM2, STUB1 AR 799/4885GABRP 2391/4885GABRD 496/4885
US-20220160695-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER AR, KLK3, SHBG AR 1/4885GABRP 2533/4885GABRD 2822/4885
US-20180086718-A1 Diarylhydantoin Compounds BPHL, AR, SHBG AR 2/4885GABRP 4199/4885GABRD 3464/4885
US-20210000812-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer AR, SHBG, KLK3 AR 1/4885GABRP 2633/4885GABRD 2171/4885
US-10933059-B2 Combination, application thereof and treatment method CYP21A2, CYP17A1, NR5A1 AR 5/4885GABRP 840/4885GABRD 639/4885
US-11185592-B2 Spirocyclic degronimers for target protein degradation STUB1, UBE3C, UBE3A AR 187/4885GABRP 4033/4885GABRD 1322/4885
US-20230338351-A1 Androgen Receptor Inhibitors For The Treatment Of Non-Metastatic Castration-Resistant Prostate Cancer In Subjects With Severe Hepatic Impairment AR, KLK3, SHBG AR 1/4885GABRP 1173/4885GABRD 1625/4885
US-20070004753-A1 N-methyl-4-{4-[7-(4-cyano-3 -trifluoromethylphenyl)-6,8-dioxo-5,7-diazaspiro[3.4]oct-5-yl]-phenyl}butyramide; for treatment of hormone refractory prostate cancer AR, BRDT, GNRHR AR 1/4885GABRP 480/4885GABRD 448/4885
US-20210106688-A1 SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION STUB1, UBE3C, UBE3A AR 187/4885GABRP 4033/4885GABRD 1322/4885
US-20140031409-A1 METHODS FOR TREATING ANDROGEN RECEPTOR DEPENDENT DISORDERS INCLUDING CANCERS AR, ESRRB, ESRRA AR 1/4885GABRP 820/4885GABRD 277/4885
US-20180318277-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer AR, SHBG, KLK3 AR 1/4885GABRP 2633/4885GABRD 2171/4885
US-20100172975-A1 TREATMENT OF HYPERPROLIFERATIVE DISORDERS WITH DIARYLHYDANTOIN COMPOUNDS CDK4, CCNH, VHL AR 113/4885GABRP 4700/4885GABRD 3973/4885
US-20150157656-A1 Method for Treatment of Castration-Resistant Prostate Cancer IGFBP5, IGFBP2, IGFBP1 AR 7/4885GABRP 1377/4885GABRD 1516/4885
US-20210128541-A1 ANDROGEN RECEPTOR INHIBITORS FOR THE TREATMENT OF NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER IN SUBJECTS WITH SEVERE HEPATIC IMPAIRMENT AR, KLK3, SHBG AR 1/4885GABRP 1173/4885GABRD 1625/4885
US-20250333385-A1 DIARYLHYDANTOIN COMPOUNDS BPHL, AR, SHBG AR 2/4885GABRP 4199/4885GABRD 3464/4885
US-20190210974-A1 DIARYLHYDANTOIN COMPOUNDS BPHL, AR, SHBG AR 2/4885GABRP 4199/4885GABRD 3464/4885
US-10799488-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer AR, SHBG, KLK3 AR 1/4885GABRP 2633/4885GABRD 2171/4885
US-20190262315-A1 Treatment of Breast Cancer BRCA1, TP53, TUBB6 AR 2403/4885GABRP 3568/4885GABRD 3622/4885
US-12303497-B2 Anti-androgens for the treatment of metastatic castration-sensitive prostate cancer AR, KLK3, SHBG AR 1/4885GABRP 2533/4885GABRD 2822/4885
US-10905768-B1 Heterocyclic degronimers for target protein degradation CRBN, MDM2, STUB1 AR 799/4885GABRP 2391/4885GABRD 496/4885
US-20170087132-A1 Treatment of Breast Cancer BRCA1, MKI67, BAX AR 2292/4885GABRP 2593/4885GABRD 3792/4885
US-20200079741-A1 DIARYLHYDANTOIN COMPOUNDS BPHL, AR, SHBG AR 2/4885GABRP 4199/4885GABRD 3464/4885
US-20170101384-A1 ANDROGEN RECEPTOR ANTAGONISTS AR, LHCGR, FSHR AR 1/4885GABRP 352/4885GABRD 182/4885
US-20150112082-A1 DIARYLHYDANTOIN COMPOUNDS BPHL, AR, SHBG AR 2/4885GABRP 4199/4885GABRD 3464/4885
US-20140296312-A1 TREATMENT OF BREAST CANCER BRCA1, BAX, BAD AR 2166/4885GABRP 2459/4885GABRD 3707/4885
US-20230190722-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER AR, KLK3, SHBG AR 1/4885GABRP 2533/4885GABRD 2822/4885
US-20120190718-A1 DIARYLTHIOHYDANTOIN COMPOUNDS AR, SHBG, PTMS AR 1/4885GABRP 3664/4885GABRD 2624/4885
US-20180055915-A1 COMPOSITIONS AND METHODS FOR TREATING PROSTATE CANCER KLK3, ACP3, AR AR 3/4885GABRP 4697/4885GABRD 4654/4885
US-11963952-B2 Anti-androgens for the treatment of metastatic castration-sensitive prostate cancer AR, KLK3, SHBG AR 1/4885GABRP 2533/4885GABRD 2822/4885
US-20240165091-A1 ANTI-ANDROGENS FOR THE TREATMENT OF METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER AR, KLK3, SHBG AR 1/4885GABRP 2533/4885GABRD 2822/4885
US-20130034501-A1 DIARYLHYDANTOIN COMPOUNDS FAP, LEF1, LPXN AR 11/4885GABRP 4859/4885GABRD 4634/4885
US-20200354334-A1 Process For The Preparation Of A Diarylthiohydantoin Compound BPHL, CYP4X1, KLK3 AR 27/4885GABRP 3804/4885GABRD 2494/4885
US-10052314-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer AR, SHBG, KLK3 AR 1/4885GABRP 2633/4885GABRD 2171/4885
US-20210069154-A1 Treatment of Breast Cancer BRCA1, TP53, TUBB6 AR 2403/4885GABRP 3568/4885GABRD 3622/4885
US-20190269667-A1 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer AR, SHBG, KLK3 AR 1/4885GABRP 2633/4885GABRD 2171/4885
US-20140371284-A1 IMIDAZOLIDINEDIONE COMPOUNDS AND THEIR USES AR, CYP19A1, CYP17A1 AR 1/4885GABRP 1462/4885GABRD 1592/4885
US-10849888-B2 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer AR, SHBG, KLK3 AR 1/4885GABRP 2633/4885GABRD 2171/4885
US-20230405094-A1 TREATMENT OR PREVENTION OF A DISEASE OR DISORDER ADAMTS5, HEXD, ADAMTS1 AR 3685/4885GABRP 3325/4885GABRD 3341/4885
US-11723898-B2 Androgen receptor inhibitors for the treatment of non-metastatic castration-resistant prostate cancer in subjects with severe hepatic impairment AR, KLK3, SHBG AR 1/4885GABRP 1173/4885GABRD 1625/4885
US-20140343111-A1 DIARYLTHIOHYDANTOIN COMPOUNDS AR, SHBG, PTMS AR 1/4885GABRP 3664/4885GABRD 2624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.