Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17110879 | 1.00 | TRPA1 (0.41) | TRPA1POLBL3MBTL1HTTALDH1A1 | |
| SCHEMBL17110958 | 1.00 | TRPA1 (0.41) | TRPA1POLBL3MBTL1HTTALDH1A1 | |
| SCHEMBL17110872 | 0.89 | TRPA1 (0.41) | TRPA1POLBL3MBTL1HTTALDH1A1 | |
| SCHEMBL17110926 | 0.89 | TRPA1 (0.41) | TRPA1POLBL3MBTL1HTTALDH1A1 | |
| SCHEMBL17110870 | 0.89 | TRPA1 (0.41) | TRPA1POLBL3MBTL1HTTALDH1A1 | |
| SCHEMBL15638540 | 0.87 | TRPA1 (0.56) | TRPA1POLBL3MBTL1HTTALDH1A1 | |
| SCHEMBL17112659 | 0.87 | TRPA1 (0.56) | TRPA1POLBL3MBTL1HTTALDH1A1 | |
| SCHEMBL17112679 | 0.87 | TRPA1 (0.56) | TRPA1POLBL3MBTL1HTTALDH1A1 | |
| SCHEMBL17112615 | 0.85 | TRPA1 (0.46) | TRPA1POLBL3MBTL1HTTALDH1A1 | |
| SCHEMBL17110910 | 0.85 | TRPA1 (0.46) | TRPA1POLBL3MBTL1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015144977-A1 | TRPA1 MODULATORS | ORIEN CORPORATION (FI) | 2015-10-01 | — | — | WO | claimed |
| WO-2015144976-A1 | TRPA1 MODULATORS | ORION CORPORATION (FI) | 2015-10-01 | — | — | WO | disclosed |
| WO-2015144977-A1 | TRPA1 MODULATORS | ORIEN CORPORATION (FI) | 2015-10-01 | — | — | WO | disclosed |