Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17110976 | 1.00 | TRPA1 (0.43) | TRPA1IRAK4SCN9AANO1MAPK8 | |
| SCHEMBL17110910 | 0.85 | TRPA1 (0.46) | TRPA1IRAK4SCN9AANO1MAPK8 | |
| SCHEMBL17112615 | 0.85 | TRPA1 (0.46) | TRPA1IRAK4SCN9AANO1MAPK8 | |
| SCHEMBL17110903 | 0.85 | TRPA1 (0.46) | TRPA1IRAK4SCN9AANO1MAPK8 | |
| SCHEMBL17110894 | 0.80 | TRPA1 (0.49) | TRPA1IRAK4ANO1MAPK8 | |
| SCHEMBL17110897 | 0.80 | TRPA1 (0.49) | TRPA1IRAK4ANO1MAPK8 | |
| SCHEMBL17110984 | 0.80 | TRPA1 (0.49) | TRPA1IRAK4ANO1MAPK8 | |
| SCHEMBL17110980 | 0.78 | TRPA1 (0.45) | TRPA1IRAK4ANO1MAPK8MAPK1 | |
| SCHEMBL15639912 | 0.77 | TRPA1 (0.71) | TRPA1IRAK4 | |
| SCHEMBL15638540 | 0.76 | TRPA1 (0.56) | TRPA1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015144977-A1 | TRPA1 MODULATORS | ORIEN CORPORATION (FI) | 2015-10-01 | — | — | WO | disclosed |