Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.48 |
| ▸ | ATR | Q13535 | 16/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17110684 | 0.89 | CYP4F2 (0.45) | CYP4F2CYP4A11ATR | |
| SCHEMBL17110705 | 0.79 | NTRK1 (0.59) | — | |
| SCHEMBL17110606 | 0.76 | ATR (0.45) | CYP4F2CYP4A11ATR | |
| SCHEMBL19881080 | 0.76 | CYP4F2 (0.48) | CYP4F2CYP4A11ATR | |
| SCHEMBL17110607 | 0.76 | CYP4F2 (0.46) | CYP4F2CYP4A11ATR | |
| SCHEMBL17110659 | 0.75 | CYP4F2 (0.43) | CYP4F2CYP4A11ATR | |
| SCHEMBL15016182 | 0.74 | CYP4F2 (0.50) | CYP4F2CYP4A11ATR | |
| SCHEMBL25261997 | 0.74 | CYP4F2 (0.44) | CYP4F2CYP4A11ATR | |
| SCHEMBL15388562 | 0.73 | CYP4F2 (0.46) | CYP4F2CYP4A11ATR | |
| SCHEMBL15388563 | 0.73 | CYP4F2 (0.46) | CYP4F2CYP4A11ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122343-A2 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | Merck Sharp & Dohme Corp. (US) | 2017-02-01 | — | — | EP | disclosed |
| EP-3122344-A2 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | Merck Sharp & Dohme Corp. (US) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015148354-A2 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |
| WO-2015148350-A2 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |