Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.38 |
| ▸ | HTR6 | P50406 | 5/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522319 | 0.81 | KDM5A (0.44) | KDM5AKDM4CKDM5BIDO1SLC6A4 | |
| SCHEMBL17112865 | 0.80 | CAMK2A (0.40) | IDO1SLC6A4SRD5A1KDM1A | |
| SCHEMBL18355881 | 0.80 | KDM5A (0.41) | KDM5AKDM4CKDM5BIDO1SLC6A4 | |
| SCHEMBL18361618 | 0.80 | KDM5A (0.41) | KDM5AKDM4CKDM5BIDO1SLC6A4 | |
| SCHEMBL17115833 | 0.75 | IDO1 (0.68) | IDO1SLC6A4 | |
| SCHEMBL7074968 | 0.74 | PGR (0.45) | KDM5AKDM4CKDM5BCYP17A1CYP3A4 | |
| SCHEMBL19273851 | 0.74 | HTR2A (0.44) | SLC6A4CYP17A1CYP3A4CYP11B2SRD5A1 | |
| SCHEMBL20491295 | 0.74 | KDM1A (0.42) | CYP17A1CYP3A4CYP11B2SRD5A1HTR6 | |
| SCHEMBL18289385 | 0.74 | KDM1A (0.42) | CYP17A1CYP3A4CYP11B2SRD5A1HTR6 | |
| SCHEMBL18053015 | 0.74 | HTR2A (0.44) | SLC6A4CYP17A1CYP3A4CYP11B2SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140133-A1 | PIPERIDINE-DIONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-09-24 | — | — | WO | disclosed |
| WO-2015142903-A2 | METHOD OF CONTROLLING LACTATE PRODUCTION WITH PIPERDINE-DIONE DERIVATIVES | GENENTECH, INC. (US) | 2015-09-24 | — | — | WO | disclosed |