Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 5/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2692672 | 1.00 | TSHR (0.34) | TSHRALDH1A1PIM1PIM3PIM2 | |
| SCHEMBL2694105 | 1.00 | TSHR (0.34) | TSHRALDH1A1PIM1PIM3PIM2 | |
| SCHEMBL2694107 | 1.00 | TSHR (0.34) | TSHRALDH1A1PIM1PIM3PIM2 | |
| SCHEMBL2692676 | 1.00 | TSHR (0.34) | TSHRALDH1A1PIM1PIM3PIM2 | |
| SCHEMBL1723165 | 1.00 | TSHR (0.34) | TSHRALDH1A1PIM1PIM3PIM2 | |
| SCHEMBL15338281 | 0.81 | — | — | |
| SCHEMBL1723397 | 0.81 | ALDH1A1 (0.40) | ALDH1A1PIM1PIM3PIM2ADRA1D | |
| SCHEMBL13833169 | 0.81 | ALDH1A1 (0.40) | ALDH1A1PIM1PIM3PIM2ADRA1D | |
| SCHEMBL13833170 | 0.81 | ALDH1A1 (0.40) | ALDH1A1PIM1PIM3PIM2ADRA1D | |
| SCHEMBL2694268 | 0.74 | PIM1 (0.45) | ALDH1A1PIM1PIM3PIM2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344474-B1 | PICOLINAMIDE DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-09-23 | — | — | EP | disclosed |