Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.71 |
| ▸ | INSR | P06213 | 7/20 | 0.71 |
| ▸ | LYN | P07948 | 5/20 | 0.71 |
| ▸ | LCK | P06239 | 4/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.71 |
| ▸ | FLT4 | P35916 | 4/20 | 0.71 |
| ▸ | KDR | P35968 | 4/20 | 0.71 |
| ▸ | FLT3 | P36888 | 4/20 | 0.71 |
| ▸ | SRC | P12931 | 3/20 | 0.71 |
| ▸ | KIT | P10721 | 3/20 | 0.71 |
| ▸ | FLT1 | P17948 | 3/20 | 0.71 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.71 |
| ▸ | RET | P07949 | 3/20 | 0.71 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.71 |
| ▸ | BTK | Q06187 | 2/20 | 0.71 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.71 |
| ▸ | EGFR | P00533 | 1/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.71 |
| ▸ | MET | P08581 | 1/20 | 0.71 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17144883 | 0.89 | IGF1R (0.71) | IGF1RINSRLYNLCKFGFR1 | |
| SCHEMBL29561027 | 0.83 | IGF1R (1.00) | IGF1RINSRLYNLCKFGFR1 | |
| SCHEMBL1441421 | 0.83 | IGF1R (1.00) | IGF1RINSRLYNLCKFGFR1 | |
| SCHEMBL1987652 | 0.83 | IGF1R (1.00) | IGF1RINSRLYNLCKFGFR1 | |
| SCHEMBL94862 | 0.83 | IGF1R (1.00) | IGF1RINSRLYNLCKFGFR1 | |
| SCHEMBL1983472 | 0.81 | IGF1R (1.00) | IGF1RINSRLYNLCKFGFR1 | |
| SCHEMBL95142 | 0.81 | IGF1R (1.00) | IGF1RINSRLYNLCKFGFR1 | |
| SCHEMBL29356373 | 0.81 | IGF1R (1.00) | IGF1RINSRLYNLCKFGFR1 | |
| SCHEMBL1983470 | 0.81 | IGF1R (1.00) | IGF1RINSRLYNLCKFGFR1 | |
| SCHEMBL30631775 | 0.81 | IGF1R (1.00) | IGF1RINSRLYNLCKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058112-A1 | ANTIBODIES | MERCK SHARP & DOHME CORP. | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058112-A1 | ANTIBODIES | IGF1R, EGFR, ERBB3 | IGF1R 1/4885INSR 20/4885LYN 474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.