Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 3/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | RAF1 | P04049 | 6/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | LYN | P07948 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13603635 | 0.91 | DDR2 (0.52) | DDR2MAPK14RAF1EPHX2KDR | |
| SCHEMBL171277 | 0.88 | MAPK14 (0.57) | DDR2MAPK14RAF1EPHX2KDR | |
| SCHEMBL15574740 | 0.86 | DDR2 (0.71) | DDR2MAPK14RAF1EPHX2KDR | |
| SCHEMBL17000002 | 0.85 | DDR2 (0.60) | DDR2MAPK14RAF1EPHX2KDR | |
| SCHEMBL17000001 | 0.82 | L3MBTL1 (0.61) | DDR2MAPK14RAF1EPHX2KDR | |
| SCHEMBL13603449 | 0.81 | DDR2 (0.59) | DDR2MAPK14RAF1EPHX2KDR | |
| SCHEMBL17000011 | 0.80 | DDR2 (0.69) | DDR2MAPK14RAF1EPHX2KDR | |
| SCHEMBL13648145 | 0.80 | KDR (0.61) | DDR2MAPK14RAF1EPHX2KDR | |
| SCHEMBL15575325 | 0.79 | DDR2 (0.59) | DDR2MAPK14RAF1EPHX2KDR | |
| SCHEMBL17000003 | 0.79 | POLB (0.58) | DDR2MAPK14RAF1EPHX2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |