Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 3/20 | 0.47 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712244 | 1.00 | EP300 (0.48) | EP300FAAHSOAT1CYP1A2CYP2C19 | |
| SCHEMBL6048387 | 0.92 | GRIK1 (0.39) | EP300FAAHSOAT1CYP1A2CYP2C19 | |
| SCHEMBL1556036 | 0.84 | GRIK1 (0.35) | FAAHSOAT1CYP1A2CYP2C19MEN1 | |
| SCHEMBL2821145 | 0.83 | EP300 (0.60) | EP300FAAHCYP1A2CYP2C19KMT2A | |
| SCHEMBL2552303 | 0.83 | EP300 (0.60) | EP300FAAHCYP1A2CYP2C19KMT2A | |
| SCHEMBL2398089 | 0.83 | EP300 (0.60) | EP300FAAHCYP1A2CYP2C19KMT2A | |
| SCHEMBL2821148 | 0.83 | EP300 (0.60) | EP300FAAHCYP1A2CYP2C19KMT2A | |
| SCHEMBL2552668 | 0.83 | EP300 (0.60) | EP300FAAHCYP1A2CYP2C19KMT2A | |
| SCHEMBL2397834 | 0.83 | EP300 (0.60) | EP300FAAHCYP1A2CYP2C19KMT2A | |
| SCHEMBL2552306 | 0.83 | EP300 (0.60) | EP300FAAHCYP1A2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343974-A2 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS | Georgetown University (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027641-A2 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS | GEORGETOWN UNIVERSITY (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010019963-A2 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS | GEORGETOWN UNIVERSITY (US) | 2010-02-18 | — | — | WO | disclosed |