Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20386594 | 0.96 | CYP1A2 (0.48) | CYP1A2CYP2D6TLR8TLR7BRD4 | |
| SCHEMBL20386612 | 0.91 | BRD4 (0.51) | CYP1A2CYP2D6TLR8TLR7BRD4 | |
| SCHEMBL21920109 | 0.83 | BRD4 (0.44) | CYP1A2CYP2D6TLR8TLR7BRD4 | |
| SCHEMBL15469718 | 0.82 | TLR8 (0.46) | TLR8TLR7BRD4PPIACYP11B1 | |
| SCHEMBL13195085 | 0.82 | TLR8 (0.50) | CYP1A2CYP2D6TLR8TLR7BRD4 | |
| SCHEMBL13195033 | 0.82 | TLR8 (0.67) | CYP1A2CYP2D6TLR8TLR7CYP3A4 | |
| SCHEMBL15469717 | 0.81 | BRD4 (0.42) | BRD4ACHEPPIAAPPCYP11B1 | |
| SCHEMBL13195028 | 0.81 | KCNH2 (0.47) | TLR8TLR7BRD4PPIA | |
| SCHEMBL21769255 | 0.79 | BRD4 (0.57) | BRD4PPIACYP11B1CYP11B2ADORA3 | |
| SCHEMBL15469714 | 0.79 | BRD4 (0.57) | BRD4PPIACYP11B1CYP11B2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790191-B2 | Substituted acylaminopyrimidines as inducers of alpha interferon production | JANSSEN SCIENCES IRELAND UC (IE) | 2017-10-17 | — | — | US | disclosed |
| US-9790191-B2 | Substituted acylaminopyrimidines as inducers of alpha interferon production | JANSSEN SCIENCES IRELAND UC (IE) | 2017-10-17 | — | — | US | disclosed |
| US-20150274676-A1 | ACYLAMINOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES | JANSSEN SCIENCES IRELAND UC (IE) | 2015-10-01 | — | — | US | disclosed |
| US-20150274676-A1 | ACYLAMINOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES | JANSSEN SCIENCES IRELAND UC (IE) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274676-A1 | ACYLAMINOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES | DPYD, TYMP, ENTPD5 | CYP1A2 1850/4885CYP2D6 481/4885TLR8 368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.