Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 2/20 | 0.62 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17055910 | 0.87 | KDM4E (0.65) | CCR8TRPV6KDM4EACKR3KMT2A | |
| SCHEMBL17124804 | 0.85 | KDM4E (0.73) | CCR8KDM4EALDH1A1ACKR3KMT2A | |
| SCHEMBL17055909 | 0.85 | CCR8 (0.67) | CCR8KDM4EKMT2A | |
| SCHEMBL17055926 | 0.85 | CCR8 (0.64) | CCR8KDM4E | |
| SCHEMBL17055931 | 0.85 | CCR8 (0.67) | CCR8LMNAKDM4EALDH1A1FAAH | |
| SCHEMBL17055980 | 0.85 | CCR8 (0.64) | CCR8KDM4EACKR3FAAH | |
| SCHEMBL17055928 | 0.85 | CCR8 (0.64) | CCR8KDM4E | |
| SCHEMBL17055982 | 0.85 | CCR8 (0.64) | CCR8KDM4EALDH1A1ACKR3FAAH | |
| SCHEMBL17055927 | 0.85 | CCR8 (0.64) | CCR8KDM4EALDH1A1 | |
| SCHEMBL17108220 | 0.84 | CCR8 (0.66) | CCR8KDM4EMAPTALDH1A1ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274657-A1 | PYRROLIDINES | MERCK PATENT GMBH (DE) | 2015-10-01 | — | — | US | disclosed |
| US-20150274657-A1 | PYRROLIDINES | MERCK PATENT GMBH (DE) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274657-A1 | PYRROLIDINES | NR4A3, NR0B1, NR0B2 | CCR8 1120/4885TRPV6 3435/4885LMNA 4761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.