Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB3 | P21860 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 9/20 | 0.52 |
| ▸ | LCK | P06239 | 8/20 | 0.52 |
| ▸ | TEK | Q02763 | 8/20 | 0.52 |
| ▸ | BTK | Q06187 | 8/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17131581 | 0.90 | ERBB3 (0.68) | ERBB3SRCLCKTEKBTK | |
| SCHEMBL15647917 | 0.90 | ERBB3 (0.57) | ERBB3SRCLCKTEKBTK | |
| SCHEMBL17132395 | 0.90 | ERBB3 (0.54) | ERBB3SRCLCKTEKBTK | |
| SCHEMBL17131580 | 0.89 | BTK (0.52) | ERBB3SRCLCKTEKBTK | |
| SCHEMBL6433918 | 0.84 | BTK (0.73) | SRCLCKTEKBTKKDR | |
| SCHEMBL29763108 | 0.84 | BTK (0.73) | SRCLCKTEKBTKKDR | |
| SCHEMBL5801409 | 0.84 | BTK (0.73) | SRCLCKTEKBTKKDR | |
| SCHEMBL6434918 | 0.84 | BTK (0.73) | SRCLCKTEKBTKKDR | |
| SCHEMBL17106409 | 0.84 | BTK (0.60) | ERBB3SRCLCKTEKBTK | |
| SCHEMBL17132402 | 0.84 | ERBB3 (0.60) | ERBB3SRCLCKTEKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-04-05 | — | — | US | disclosed |
| US-9758522-B2 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-20150274738-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | Dana-Farber Cancer, Institute, Inc. (US) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274738-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | MYC, TP53, MDM2 | ERBB3 16/4885SRC 322/4885LCK 401/4885 |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | MYC, TP53, MDM2 | ERBB3 16/4885SRC 322/4885LCK 401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.