Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3360038 | 1.00 | LMNA (0.39) | LMNACYP3A4MEN1ALOX15KMT2A | |
| SCHEMBL28731962 | 0.88 | USP2 (0.35) | CYP3A4TSHRCYP2C19FFAR1FFAR4 | |
| SCHEMBL28961040 | 0.86 | CYP3A4 (0.38) | CYP3A4MEN1ALOX15KMT2ATSHR | |
| SCHEMBL22492533 | 0.82 | FFAR1 (0.49) | LMNATSHRFFAR1FFAR4ALDH1A1 | |
| SCHEMBL5907166 | 0.82 | CYP3A4 (0.33) | CYP3A4TSHRCYP2C19FFAR1FFAR4 | |
| SCHEMBL789882 | 0.82 | FFAR1 (0.49) | LMNATSHRFFAR1FFAR4ALDH1A1 | |
| SCHEMBL9685329 | 0.80 | FFAR1 (0.52) | LMNATSHRFFAR1FFAR4FAAH | |
| SCHEMBL9685588 | 0.80 | FFAR1 (0.52) | LMNATSHRFFAR1FFAR4FAAH | |
| SCHEMBL9334962 | 0.80 | FFAR1 (0.52) | LMNATSHRFFAR1FFAR4FAAH | |
| SCHEMBL1712736 | 0.80 | FFAR1 (0.52) | LMNATSHRFFAR1FFAR4FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343974-A2 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS | Georgetown University (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027641-A2 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS | GEORGETOWN UNIVERSITY (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010019963-A2 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS | GEORGETOWN UNIVERSITY (US) | 2010-02-18 | — | — | WO | disclosed |