Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 5/20 | 0.43 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.43 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.43 |
| ▸ | POLG | P54098 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.38 |
| ▸ | POLRMT | O00411 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106860 | 1.00 | P2RY1 (0.43) | P2RY1P2RY2P2RY11POLGP2RX1 | |
| SCHEMBL17111278 | 1.00 | P2RY1 (0.43) | P2RY1P2RY2P2RY11POLGP2RX1 | |
| SCHEMBL17130388 | 0.91 | P2RY2 (0.42) | P2RY1P2RY2P2RY11P2RX1P2RX3 | |
| SCHEMBL17114351 | 0.91 | P2RY2 (0.42) | P2RY1P2RY2P2RY11P2RX1P2RX3 | |
| SCHEMBL17111226 | 0.91 | P2RY1 (0.42) | P2RY1P2RY2P2RY11P2RX1P2RX3 | |
| SCHEMBL17106737 | 0.91 | P2RY1 (0.42) | P2RY1P2RY2P2RY11P2RX1P2RX3 | |
| SCHEMBL18521055 | 0.88 | TAS1R3 (0.36) | — | |
| SCHEMBL18670625 | 0.87 | P2RY1 (0.43) | P2RY1P2RY2P2RY11POLG | |
| SCHEMBL19412751 | 0.87 | P2RY1 (0.45) | P2RY1P2RY2P2RY11POLGP2RX1 | |
| SCHEMBL17106665 | 0.85 | P2RY2 (0.43) | P2RY1P2RY2P2RY11POLGP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015143712-A1 | 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |