Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | STK3 | Q13188 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.45 |
| ▸ | BLK | P51451 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14321208 | 0.90 | PDE5A (0.52) | ROCK2ROCK1SYKCLK2STK3 | |
| SCHEMBL14320502 | 0.87 | FGFR1 (0.48) | ROCK2ROCK1MEN1KMT2ASYK | |
| SCHEMBL14320672 | 0.84 | ABCG2 (0.54) | MEN1KMT2ASYKABCG2 | |
| SCHEMBL15652843 | 0.82 | ABCG2 (0.54) | ROCK2ROCK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14320390 | 0.82 | ABCG2 (0.53) | ROCK2ROCK1MEN1KMT2ASYK | |
| SCHEMBL14320987 | 0.82 | FGFR1 (0.54) | ROCK2SYKL3MBTL1CLK4ALDH1A1 | |
| SCHEMBL17135651 | 0.81 | SYK (0.47) | ROCK2ROCK1KMT2ASYKCLK2 | |
| SCHEMBL14320319 | 0.80 | MEN1 (0.43) | ROCK2ROCK1MEN1KMT2ASYK | |
| SCHEMBL14320680 | 0.80 | SYK (0.46) | SYKALDH1A1SMN1; SMN2POLBABCG2 | |
| SCHEMBL14320484 | 0.80 | ABCG2 (0.65) | MEN1KMT2ASYKALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-B1 | PYRAZOLO[4,3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2015-10-07 | — | — | EP | claimed |