Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 10/20 | 0.47 |
| ▸ | MARK4 | Q96L34 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.34 |
| ▸ | SIK1 | P57059 | 1/20 | 0.34 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.34 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.34 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.34 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15578951 | 0.84 | MARK3 (0.46) | MARK3MARK4CDK2CCNE1NUAK1 | |
| SCHEMBL18824444 | 0.77 | MARK3 (0.39) | MARK3MARK4CDK2CCNE1 | |
| SCHEMBL6073476 | 0.76 | LCK (0.38) | MARK3HTR2AHTR2CHTR2BKCNH2 | |
| SCHEMBL28767333 | 0.73 | MARK3 (0.50) | MARK3MARK4CDK2CCNE1NUAK1 | |
| SCHEMBL15578846 | 0.71 | MARK3 (0.43) | MARK3MARK4CDK2CCNE1MAPK1 | |
| SCHEMBL16322702 | 0.70 | MARK3 (0.36) | MARK3MARK4CDK2CCNE1 | |
| SCHEMBL15578995 | 0.70 | MARK3 (0.41) | MARK3MARK4CDK2CCNE1NUAK1 | |
| SCHEMBL18850750 | 0.69 | MARK3 (0.40) | MARK3MARK4CDK2CCNE1MAPK1 | |
| SCHEMBL16321780 | 0.67 | MARK3 (0.47) | MARK3MARK4CDK2CCNE1NUAK1 | |
| SCHEMBL15210247 | 0.67 | MARK3 (0.46) | MARK3MARK4CDK2CCNE1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895476-B1 | 2-OXO-2,3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2016-06-22 | — | — | EP | disclosed |
| US-9221816-B2 | 2-oxo-2,3-dihydro-indoles for the treatment of CNS disorders | HOFFMANN LA-ROCHE INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150284386-A1 | 2-OXO-2,3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-08 | — | — | US | disclosed |
| CN-104619701-A | 2-oxo-2,3-dihydro-indoles for the treatment of cns disorders | HOFFMANN LA ROCHE | 2015-05-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284386-A1 | 2-OXO-2,3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS | HCRTR2, TPH2, CNR2 | MARK3 1912/4885MARK4 3800/4885CDK2 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.