Sugi Predict

Sugi Predict / Targets / TPH2

TPH2

Tryptophan 5-hydroxylase 2 · Q8IWU9 · TPH2 on Sugi Atlas →

4,396 patent compounds predicted against TPH2, 3,561 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL9707269 SCHEMBL9707269 0.47 19/20
SCHEMBL9708297 SCHEMBL9708297 0.50 18/20
SCHEMBL9708124 SCHEMBL9708124 0.49 17/20
SCHEMBL4623661 SCHEMBL4623661 0.47 17/20
SCHEMBL6265951 SCHEMBL6265951 0.60 14/20
SCHEMBL9707767 SCHEMBL9707767 0.44 14/20
SCHEMBL307901 SCHEMBL307901 1.00 11/20
SCHEMBL308221 SCHEMBL308221 1.00 11/20
SCHEMBL308718 SCHEMBL308718 1.00 11/20
SCHEMBL308719 SCHEMBL308719 1.00 11/20
SCHEMBL609905 SCHEMBL609905 1.00 11/20
SCHEMBL609906 SCHEMBL609906 1.00 11/20
SCHEMBL609907 SCHEMBL609907 1.00 11/20
SCHEMBL869552 SCHEMBL869552 1.00 11/20
SCHEMBL870344 SCHEMBL870344 1.00 11/20
SCHEMBL870345 SCHEMBL870345 1.00 11/20
SCHEMBL1333338 SCHEMBL1333338 1.00 11/20
SCHEMBL1333341 SCHEMBL1333341 1.00 11/20
SCHEMBL2364480 SCHEMBL2364480 1.00 11/20
Maleic Acid Maleic Acid (SCHEMBL2720175) 0.93 11/20

Clinical trials — most relevant to TPH2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism PHASE4COMPLETED
A Study on the Efficacy of Agomelatine Combined With Antipsychotics to Treat Negative Symptoms in Schizophrenia PHASE4UNKNOWN
The Effect of 5-Hydroxytryptophan (5-HTP) on Satiety PHASE2COMPLETED
The Neurobiological Effect of 5-HT2AR Modulation PHASE1RECRUITING
Investigating Serotonin Signalling in IBD Patients nanRECRUITING
Serotonin, Serotonin Genetics(TPH2) and Emotion and Interference Processing nanUNKNOWN
Genetic Variants Associated With Adolescent Suicide Attempts nanCOMPLETED
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke nanCOMPLETED
Tryptophan Metabolism in Healthy Young Adults nanCOMPLETED
Epigenetic and Neurochemical Correlates of Bipolar Disorder nanNOT_YET_RECRUITING
An Assessment of Cognitive Function in Irritable Bowel Syndrome nanUNKNOWN
A Longitudinal Study of Inflammatory Pathways in Depression nanCOMPLETED
Psychobiological Characterization of Depression in Hepatitis C nanUNKNOWN
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram nanCOMPLETED
Genetic and Biochemical Markers of Interferon-Induced Depression. nanCOMPLETED
Effects of Saffron and Chamomile in Mild to Moderate Depression nanUNKNOWN
Serotonin Function During Depression nanCOMPLETED
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients nanUNKNOWN
Trazodone and the Risk of Serious Adverse Events nanCOMPLETED
Probiotic Supplementation in Severe Depression nanCOMPLETED
Effect of Vitamin D Administration Along With SSRIs in Patients With Major Depressive Disorder nanUNKNOWN
PhaRmacOgenetics and Therapeutic Drug Monitoring In SchizophrEnia nanNOT_YET_RECRUITING
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors nanCOMPLETED
PET Whole Body Distribution Studies Using [11C]CUMI nanCOMPLETED
Analysis of Peripheral Serotonin Levels in a Control Cohort nanCOMPLETED
The Effect of Acute Minocycline Administration on Emotional Processing and Cognition in Healthy Volunteers nanCOMPLETED
A PK/PD Genetic Variation Treatment Algorithm Versus Treatment As Usual for Adolescent Management Of Depression nanCOMPLETED
Therapeutic Outcomes of Selective Serotonin Reuptake Inhibitors and Phosphodiesterase-5 Inhibitors Combination Therapy Versus Monotherapy nanNOT_YET_RECRUITING
Serotonin Variants & Gut Microbiota in Mental Health nanNOT_YET_RECRUITING
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a TPH2 binder may also engage these)

ProteinNameSimilarity
Q0EAB8 — 1.000 Q0EAB8 →
Q2HZ26 — 1.000 Q2HZ26 →
Q8CGU9 — 1.000 Q8CGU9 →
Q8CGV2 — 1.000 Q8CGV2 →
P09810 — 1.000 P09810 →
P11982 — 1.000 P11982 →
P17276 — 1.000 P17276 →
TPH1 Tryptophan 5-hydroxylase 1 1.000 landscape →
P17290 — 1.000 P17290 →
P70080 — 0.999 P70080 →
Q92142 — 0.998 Q92142 →
Q2KIH7 — 0.997 Q2KIH7 →
E5KBU3 — 0.997 E5KBU3 →
A0A060X6Z0 — 0.997 A0A060X6Z0 →
PAH Phenylalanine-4-hydroxylase 0.996 landscape →
P16331 — 0.996 P16331 →
P04176 — 0.995 P04176 →
P24529 — 0.995 P24529 →
P04177 — 0.994 P04177 →
P90925 — 0.994 P90925 →
A8X3V8 — 0.994 A8X3V8 →
P17532 — 0.993 P17532 →
P17289 — 0.993 P17289 →
Q76IQ3 — 0.992 Q76IQ3 →
P90986 — 0.992 P90986 →
Q54XS1 — 0.992 Q54XS1 →
E5KBU4 — 0.992 E5KBU4 →
Q9STV0 — 0.990 Q9STV0 →
P83372 — 0.990 P83372 →
Q8CFQ3 — 0.990 Q8CFQ3 →