Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22777530 | 0.88 | NPC1 (0.47) | NPC1RAB9AMAPTCYP1A2CYP2C9 | |
| SCHEMBL11280539 | 0.84 | NPC1 (0.61) | NPC1RAB9AMAPTPTGDR2CYP1A2 | |
| SCHEMBL28694748 | 0.84 | TDP1 (0.62) | MAPTTDP1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL22777216 | 0.83 | CYP1A2 (0.64) | NPC1MAPTCYP1A2CYP2C9HIF1A | |
| SCHEMBL22777269 | 0.82 | MTNR1A (0.47) | PTGDR2CYP1A2CYP2C9HIF1ATDP1 | |
| SCHEMBL22396983 | 0.82 | CYP1A2 (0.46) | MAPTPTGDR2CYP1A2CYP2C9HIF1A | |
| SCHEMBL12145811 | 0.82 | GAA (0.58) | NPC1RAB9AMAPTCYP1A2CYP2C9 | |
| SCHEMBL16738600 | 0.81 | MEN1 (0.50) | CYP1A2CYP2C9HIF1ATDP1KMT2A | |
| SCHEMBL3691062 | 0.81 | PTGDR2 (0.68) | NPC1RAB9AMAPTPTGDR2TDP1 | |
| SCHEMBL27833990 | 0.81 | MAPT (0.65) | MAPTPTGDR2CYP1A2CYP2C9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101107226-B | Phenoxyacetic acid derivatives useful for treating respiratory diseases | ASTRAZENECA AB | 2012-01-18 | — | — | CN | disclosed |
| EP-1817282-B1 | PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES | ASTRAZENECA AB (SE) | 2011-07-20 | — | — | EP | disclosed |
| CN-101107226-A | Phenoxyacetic acid derivatives useful for treating respiratory diseases | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | CN | disclosed |